Detailed information of TA system TA172796

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3280714..3281935
• Replicon: chromosome
• Accession: NZ_CP061699
• Organism: Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0C7CS07
• Locus tag: LYSZa7_RS15305
• Protein ID: WP_003102740.1
• Coordinates: 3280714..3281292 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LYSZa7_RS15310
• Protein ID: WP_200199626.1
• Coordinates: 3281381..3281935 (-)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYSZa7_RS15290	3275990..3277267	+	1278	WP_003088104.1	TolC family protein	-
LYSZa7_RS15295	3277257..3279428	+	2172	WP_023106617.1	type I secretion system permease/ATPase	-
LYSZa7_RS15300	3279418..3280605	+	1188	WP_022580287.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LYSZa7_RS15305	3280714..3281292	-	579	WP_003102740.1	HD domain-containing protein	Toxin
LYSZa7_RS15310	3281381..3281935	-	555	WP_200199626.1	helix-turn-helix domain-containing protein	Antitoxin
LYSZa7_RS15315	3282093..3284288	-	2196	WP_200199627.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
LYSZa7_RS15320	3284293..3284754	-	462	WP_003102736.1	(2Fe-2S)-binding protein	-
LYSZa7_RS15325	3285085..3285408	+	324	WP_003102734.1	multidrug efflux SMR transporter	-
LYSZa7_RS15330	3285421..3285819	+	399	WP_023436383.1	NADH-quinone oxidoreductase subunit A	-
LYSZa7_RS15335	3285816..3286367	-	552	WP_200199628.1	XRE family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HD domain (16-170)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21869.70 Da
• Isoelectric Point: 5.3655

>T172796 WP_003102740.1 NZ_CP061699:c3281292-3280714 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T172796 NZ_CP079931:457738-458127 [Acinetobacter baumannii]
TTGATCAACCATTTGAATTTTAAGCTGAAATATAGTCGTTTTTCGATTATATTTCAGTTTTTTATTGGCTTAAGCTTAGC
AGTTCTATTTTATCAATTAATGCCGTTACTATGGTGGTTAGTTGTAATCAGCTTACTATTTATCAACTTTATTTTCTTTT
TAAAGCGTCCGCAGCTTGCACAAATTGCTTATTTAGATAAAAAACTATGGTCGCTTGCTTATCATTCACAGAACACCATT
TCTCGCGTCAAAATTTTAAAAATAATTGATTATCAGATTTTCATAGTGATCTATTTTGAAGGTCATAAAAAACTAACTTC
TATCATTTGGTTTGATCAAATGTCATTAACAGAGTGGAAAAAGCTTAAAACTTTAGAAAAACTCTATTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20427.65 Da
• Isoelectric Point: 8.9481

>AT172796 WP_200199626.1 NZ_CP061699:c3281935-3281381 [Pseudomonas aeruginosa]
MTKPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAAPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT172796 NZ_CP079931:457474-457731 [Acinetobacter baumannii]
ATGTCTGAAGAAATGACCTTGGAAGAACGTAAAGTAATCTATCGCGCACGTCGTGGTTTAAAGGAAATTGATGTCTATTT
TGACCCTTATGTGAAAAATTATTATTTAAAGGCAGACCCGGCAGAAAAAGCGTTGTTTGCTGAGTTGGTAGAACAGGAAG
ACCCTGATTTACTAGATTGGTTTATGGAAGTATCAGAACCACCACGTACCGAATTACGTGACTTTATCTATAAATTAAAA
CACTATGTTCATGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0C7CS07