Detailed information of TA system TA172795

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 2332285..2333543
• Replicon: chromosome
• Accession: NZ_CP061699
• Organism: Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: LYSZa7_RS10830
• Protein ID: WP_003086331.1
• Coordinates: 2332788..2333543 (+)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LYSZa7_RS10825
• Protein ID: WP_003086329.1
• Coordinates: 2332285..2332653 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LYSZa7_RS10805	2328449..2328724	+	276	WP_023088486.1	zinc ribbon domain-containing protein	-
LYSZa7_RS10810	2328727..2329203	-	477	WP_009877993.1	elongation factor GreAB	-
LYSZa7_RS10815	2329281..2330870	+	1590	WP_078451948.1	aldehyde dehydrogenase family protein	-
LYSZa7_RS10820	2330926..2332212	+	1287	WP_023126426.1	FAD-binding oxidoreductase	-
LYSZa7_RS10825	2332285..2332653	+	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LYSZa7_RS10830	2332788..2333543	+	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
LYSZa7_RS10835	2334313..2335674	+	1362	WP_003081943.1	DNA recombination protein RmuC	-
LYSZa7_RS10840	2335829..2338372	-	2544	WP_200200474.1	penicillin acylase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T172795 WP_003086331.1 NZ_CP061699:2332788-2333543 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T172795 NZ_CP079927:550362-550703 [Enterococcus faecium]
GTGTCAGAAGAAAGAATTTATATTCCTAAAAAAGGTGATATTGTATGGATTGATTTTGATCCCTCCGTAGGAAAAGAAAT
TCAAAAAAGACGACCAGGACTAGTCGTCTCTCGTTATGAATTTAACCGTAAAACAATGTTTTCGGTCATATGTCCAATTA
CTTCCACTATAAAGAATTTACCGACACGTTACTCATTACCTGAAGAGCTAGATATAAAAGGACAAGTAATTATTACACAA
TTAAAATCTCTTGATTTTAAGGAACGAAAACTCAAAAAAATAGAAAACTTACCATTGCAAGACATGGCTAAAATTGATCA
GATTATACAGTATATGTTTTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT172795 WP_003086329.1 NZ_CP061699:2332285-2332653 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT172795 NZ_CP079927:550132-550362 [Enterococcus faecium]
ATGCTTGTTACAAAATCTAGATTACAAGGAAGTTCTGTAGTGGTAACTTTACCTTCTGATAACGGAAAGAAACCTTCAGA
AAACCAAGAATATATCGTTGTGTATTCTGATGATGGAACAATTACGTTAGTTCCAAAAATTGAAGATCCATTTAGTGGTG
GGGAAGAGGCCGAGTATTATGAGAAAGACGAATGGGAAGATTTAACTCCTGAAGGGAGAGAAATTTTATAG

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7