Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PfiT-PfiA/ParE(toxin)
Location 1823104..1823712 Replicon chromosome
Accession NZ_CP061699
Organism Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)


Gene name PfiT Uniprot ID A0A509JBR4
Locus tag LYSZa7_RS08340 Protein ID WP_031638390.1
Coordinates 1823365..1823712 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name PfiA Uniprot ID A0A0B0C355
Locus tag LYSZa7_RS08335 Protein ID WP_003114155.1
Coordinates 1823104..1823355 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa7_RS08315 1818189..1819268 - 1080 WP_200200359.1 hypothetical protein -
LYSZa7_RS08320 1820055..1821193 + 1139 WP_086009431.1 IS3 family transposase -
LYSZa7_RS08325 1821224..1821907 + 684 Protein_1633 hypothetical protein -
LYSZa7_RS08330 1821907..1822890 + 984 WP_200200360.1 tyrosine-type recombinase/integrase -
LYSZa7_RS08335 1823104..1823355 + 252 WP_003114155.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LYSZa7_RS08340 1823365..1823712 + 348 WP_031638390.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LYSZa7_RS08345 1824322..1824621 + 300 WP_200200608.1 helix-turn-helix domain-containing protein -
LYSZa7_RS08350 1824618..1825580 + 963 WP_200200361.1 patatin-like phospholipase family protein -
LYSZa7_RS08355 1825596..1826489 + 894 WP_200200362.1 nucleotidyltransferase -
LYSZa7_RS08360 1826571..1828289 + 1719 WP_200200609.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp1 1819486..1863554 44068


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13018.79 Da        Isoelectric Point: 4.4212

>T172794 WP_031638390.1 NZ_CP061699:1823365-1823712 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLVPFQGEQAAFQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE

Download         Length: 348 bp

>T172794 NZ_CP079927:222886-223152 [Enterococcus faecium]
ATGAGTAACTATACAGTCGCAATCAAAAACTCTGCGAAAGTGGATTTAAGAAAAATCAAGCAAACGAATTTAAAGAAACA
ATTTGAAGAAGTGATTCAGACATTGAAGGAAGATCCATATATGCCCACGCAGTCTTTTGAAAAGCTGAGACCTACACATG
AAGGCAGATACTCACGCAGGCTGAATAGACAGCATCGAGTGGTTTACAAAGTTGATGAGGAAAATAAAGTTGTAGAAATT
TATTCTGCCTGGACACATTATGAGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9442.79 Da        Isoelectric Point: 9.4808

>AT172794 WP_003114155.1 NZ_CP061699:1823104-1823355 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE

Download         Length: 252 bp

>AT172794 NZ_CP079927:222623-222886 [Enterococcus faecium]
ATGGCTAATACAACGATGAATCCTAGCACTGCTCGTAAAAATTTTTATCAGTTATTGAAAGAGGTAAATGAAAATCATAC
TGAAATCGAGATTATTAGTGATCGTAGTGGAAACAATGCTGTATTGATTGGGCTGGAAGACTGGAGAGCGATTCAAGAAA
CCCTTTTTCTTGAGCAAACAGGTACTTTAGATAAAGTACGAGACCGCGAAAAAGACGACAGTAGCTTTACGAATATCGAT
GATATTGATTGGGAAGCTCTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JBR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0B0C355

References