Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 50197..50702 Replicon chromosome
Accession NZ_CP061699
Organism Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag LYSZa7_RS00230 Protein ID WP_003083773.1
Coordinates 50421..50702 (+) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A0H2ZJU8
Locus tag LYSZa7_RS00225 Protein ID WP_003137009.1
Coordinates 50197..50424 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa7_RS00200 45210..46703 + 1494 WP_003083788.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -
LYSZa7_RS00205 46872..48299 + 1428 WP_052157160.1 GABA permease -
LYSZa7_RS00210 48386..48727 - 342 WP_003101229.1 alkylphosphonate utilization protein -
LYSZa7_RS00215 48800..49300 - 501 WP_003101228.1 LEA type 2 family protein -
LYSZa7_RS00220 49401..50021 + 621 WP_003101226.1 hypothetical protein -
LYSZa7_RS00225 50197..50424 + 228 WP_003137009.1 CopG family ribbon-helix-helix protein Antitoxin
LYSZa7_RS00230 50421..50702 + 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
LYSZa7_RS00235 51002..51910 + 909 WP_200200141.1 LysR family transcriptional regulator -
LYSZa7_RS00240 51942..52328 - 387 WP_003083767.1 aegerolysin family protein -
LYSZa7_RS00245 52532..53266 - 735 WP_023107524.1 GntR family transcriptional regulator -
LYSZa7_RS00250 53367..54053 - 687 WP_003083762.1 FadR family transcriptional regulator -
LYSZa7_RS00255 54102..55451 - 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T172792 WP_003083773.1 NZ_CP061699:50421-50702 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T172792 NZ_CP079926:3414520-3414795 [Caulobacter vibrioides]
GTGGCGCAAGTAGTCTGGACCCAACGAGCGATGGCCGATGTTTACGCCATCGTCGGCCATATCTCCGAGCAGTCGCGTCC
TCTCGCGGCCCAGCGCCTGGCCAAGAGGTTGTTCGACACCGGCGCTAGCCTGGCGACCTATCCCGAACGCGGGCGCGTGA
GCACTCAAGGACGGCGTGAGATCGTCGCGATTTCGCCCTACGTTCTGCGCTACCGCATTGTCGGCGACCGTGTCGTCATT
GGCAGCGTACGCCATGGGGCGCGTCGACCTATCTAG

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8526.56 Da        Isoelectric Point: 5.5740

>AT172792 WP_003137009.1 NZ_CP061699:50197-50424 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHAEIEKRWGLQ

Download         Length: 228 bp

>AT172792 NZ_CP079926:3414353-3414532 [Caulobacter vibrioides]
ATGGCCGAGCCTGACCCCGACATCTTCGACGAGGACGATGAAGCGATCCTGGCGGCTGACGCCGAGGCTGACGCCGACTT
CGAAGCCGGTAGAACTGTTCCGCACGAGCGTGTGGGCGAGTGGCTCAAGACGTTGGGCACGCCGCACCAGACACCGCCAC
CATATTCGTGGCGCAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2ZJU8

References