Detailed information of TA system TA172788

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1145934..1146453
• Replicon: chromosome
• Accession: NZ_CP061681
• Organism: Acinetobacter seifertii strain AS9

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IC766_RS05420
• Protein ID: WP_032007341.1
• Coordinates: 1145934..1146215 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8B5UBP1
• Locus tag: IC766_RS05425
• Protein ID: WP_029424561.1
• Coordinates: 1146205..1146453 (-)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC766_RS05390	1141040..1142242	+	1203	WP_069119584.1	tyrosine-type recombinase/integrase	-
IC766_RS05395	1142268..1142648	+	381	WP_069119590.1	hypothetical protein	-
IC766_RS05400	1142979..1143899	+	921	WP_191029449.1	hypothetical protein	-
IC766_RS05405	1143917..1144111	+	195	WP_032007344.1	hypothetical protein	-
IC766_RS05410	1144182..1144583	-	402	WP_032007343.1	helix-turn-helix transcriptional regulator	-
IC766_RS05415	1144689..1145654	+	966	WP_191029450.1	hypothetical protein	-
IC766_RS05420	1145934..1146215	-	282	WP_032007341.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IC766_RS05425	1146205..1146453	-	249	WP_029424561.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IC766_RS05430	1146456..1146860	-	405	WP_191029451.1	hypothetical protein	-
IC766_RS05435	1146905..1147501	-	597	WP_191029452.1	recombinase family protein	-
IC766_RS05440	1148035..1149558	+	1524	WP_069119608.1	hypothetical protein	-
IC766_RS05445	1149542..1150300	+	759	WP_191029453.1	hypothetical protein	-
IC766_RS05450	1150320..1151237	+	918	WP_191029454.1	nucleotide-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10843.66 Da
• Isoelectric Point: 10.2259

>T172788 WP_032007341.1 NZ_CP061681:c1146215-1145934 [Acinetobacter seifertii]
MSYNLDFLEEALEEWNKLNPSIKQPMKKKLMKVLENPRIPKNKLSGHPNRYKIKLRSVGYRLVYEIIDDEVVVLVIAVGR
RENNAVYNTAGSR

Nucleotide

• Length: 282 bp

>T172788 NZ_CP079926:c891024-890743 [Caulobacter vibrioides]
TTGACCTTCACGGTTTTGGTATCCGTTCGGGCCAAGAGAGACTTCAACCGTCTCATCGTCTGGCTTGTGGAGCGCGACCC
CCGAGCAGCGGCTAGACTGGGCCCACTTCTGGAGGCCGCCCTCGACAGTTTGACCGAGGCGCCATCGCGAGGTCGCTCGG
TTGGTCCCACCACCCGCGAGATCAGCATTCCTTTTGGTCAGAGCGCCTATGTGATCCGCTACCGGCTCCTCGGCTCCAGC
GTACATGTCACCCGGATCTGGCACGGCCTTGAGCAAAGGTAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9272.74 Da
• Isoelectric Point: 5.8061

>AT172788 WP_029424561.1 NZ_CP061681:c1146453-1146205 [Acinetobacter seifertii]
MTQLIHARMTASITELKKSPMDTVLAGKGEAVAILNRNTPAFYCIPADLYENMIEQLEDLELNKIADTRANQKRIRVNIN
EL

Nucleotide

• Length: 249 bp

>AT172788 NZ_CP079926:c891284-891021 [Caulobacter vibrioides]
ATGGCCGATGGCTTCGACATTCATATCGATCAAGAGCAGGCCGCCCGGCTGAAGGTCGTTGCCGACCGCCTGGGTATGTC
CGTGTCCGAGTACGCCGTTGCGCTGATCGACGCAGGGCTGACAGGCGCGGCGCCTAAAGCGATCGATCCGGACCCCGCCA
TCGACGAGGCCATCGCCGACGCCATCGAGCGGGGCGACGAGCCGGCGATTTCACGCGATGAGTTCCGCGCTCATATACGT
CGCGTGACTGCGGGCCTGGGTTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B5UBP1