Detailed information of TA system TA172779

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1898907..1900543
• Replicon: chromosome
• Accession: NZ_CP061664
• Organism: Acinetobacter seifertii strain AS28

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IC772_RS08890
• Protein ID: WP_191017477.1
• Coordinates: 1898907..1900238 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: N8S5T2
• Locus tag: IC772_RS08895
• Protein ID: WP_004701524.1
• Coordinates: 1900235..1900543 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC772_RS08875	1895576..1896814	+	1239	WP_080961402.1	TolC family protein	-
IC772_RS08880	1896807..1897970	+	1164	WP_191017473.1	hypothetical protein	-
IC772_RS08885	1898172..1898612	-	441	WP_191017475.1	HD domain-containing protein	-
IC772_RS08890	1898907..1900238	+	1332	WP_191017477.1	HipA domain-containing protein	Toxin
IC772_RS08895	1900235..1900543	+	309	WP_004701524.1	helix-turn-helix domain-containing protein	Antitoxin
IC772_RS08900	1901270..1901818	+	549	WP_191017479.1	TetR/AcrR family transcriptional regulator	-
IC772_RS08905	1902045..1902665	+	621	WP_191017480.1	hypothetical protein	-
IC772_RS08910	1902686..1903768	+	1083	WP_191017482.1	XRE family transcriptional regulator	-
IC772_RS08915	1903810..1904325	+	516	WP_191017484.1	hypothetical protein	-
IC772_RS08920	1904334..1905308	-	975	WP_191017486.1	DUF4365 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-365)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50980.81 Da
• Isoelectric Point: 5.0417

>T172779 WP_191017477.1 NZ_CP061664:1898907-1900238 [Acinetobacter seifertii]
MKKLTIQALLNKNWIDIAELKLLEPTLGSASASELEYELDYAIQYSDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKDDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQQVWIDTYQQQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWRDQSWHRHGLESVYSILNKSSGSHLNHFEVIEELCRLLTSIDSDFDASQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLATWCDPAVSLATLK
TLANNLLGLRQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T172779 NZ_CP079924:c2369857-2369681 [Escherichia sp. TC-EC600-tetX4]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11590.52 Da
• Isoelectric Point: 9.9701

>AT172779 WP_004701524.1 NZ_CP061664:1900235-1900543 [Acinetobacter seifertii]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYATLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPSE

Nucleotide

• Length: 309 bp

>AT172779 NZ_CP079924:c2369635-2369219 [Escherichia sp. TC-EC600-tetX4]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA

Structures

Antitoxin

• AlphaFold DB: N8S5T2