Detailed information of TA system TA172755

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-paaA/RelE(toxin)
• Location: 35715..36165
• Replicon: plasmid pAS51-3
• Accession: NZ_CP061616
• Organism: Acinetobacter seifertii strain AS51

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IC783_RS21945
• Protein ID: WP_059273176.1
• Coordinates: 35715..35990 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: paaA
• Uniprot ID: -
• Locus tag: IC783_RS21950
• Protein ID: WP_004949557.1
• Coordinates: 35977..36165 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC783_RS21935	32103..35078	+	2976	WP_064851181.1	conjugal transfer protein TraG N-terminal domain-containing protein	-
IC783_RS21940	35123..35671	+	549	WP_004949551.1	transglycosylase SLT domain-containing protein	-
IC783_RS21945	35715..35990	-	276	WP_059273176.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IC783_RS21950	35977..36165	-	189	WP_004949557.1	hypothetical protein	Antitoxin
IC783_RS21955	36285..36983	-	699	WP_004949560.1	DNA adenine methylase	-
IC783_RS21960	37431..37964	-	534	WP_004949563.1	hypothetical protein	-
IC783_RS21965	38395..38718	+	324	WP_004949566.1	H-NS histone family protein	-
IC783_RS21970	38827..39105	-	279	WP_004949569.1	hypothetical protein	-
IC783_RS21975	39151..39426	-	276	WP_004949572.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..66816	66816

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-79)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10438.94 Da
• Isoelectric Point: 5.0825

>T172755 WP_059273176.1 NZ_CP061616:c35990-35715 [Acinetobacter seifertii]
MLIVEWTPNAIEDLEAISDYIAEHNPIAAYNLEDHILKCAESLSEHPYKGVSGRVVGTREMLVHPNYWLIYEVSDMIKIK
GVLHTRKSYPD

Nucleotide

• Length: 276 bp

>T172755 NZ_CP079921:c1780802-1780404 [Actinobacillus pleuropneumoniae]
ATGCTGGCTTATATGCTTGATACTAATATTGCGATTTATGTGATTAAACGCAGACCTATTGAAGTGCTGGATAAGTTTAA
TTTAAATTCTACTCGTCTTTGTGTAAGTAGTATCACTGCAGCGGAGTTGTATTATGGTGCAGAGAAAAGCCAGTTTCCGG
AACGAAATATGGCAGTAATTGAGGATTTTCTTTCTCGTTTAACGATTCTTGATTATACGCATAAGGCGGCTACTCACTTT
GGCAATATTAAAGCACATTTATCTAAGCAAGGTAAGATCATTGGCGAGAACGATATTCATATTGCCGCACATGCAAGAAG
TGAAGGACTCGTATTAGTGACCAATAACTTGCGTGCATTTGAACGTGTGGAAGGATTGCGATTAGATAATTGGGTATAG

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7309.13 Da
• Isoelectric Point: 7.2031

>AT172755 WP_004949557.1 NZ_CP061616:c36165-35977 [Acinetobacter seifertii]
MNTVFDPIVSEFDSSDHESEYNAWFKAKIEKSMADTRPTVPHDQVVARLKKRREERTTNVNR

Nucleotide

• Length: 189 bp

>AT172755 NZ_CP079921:c1781032-1780802 [Actinobacillus pleuropneumoniae]
ATGGAAGCATCGGTATTTATGACAAACCGTAGTCAGGCGGTACGATTACCTGCAGAAGTGCGTTTTGCAAGTGATGTAAA
AAAACTTTCTGTAAGAGTGGTAGGCAATGAACGTATTTTGGCTCCAATTAACCAAAGTTGGGATAGCTTCTTTCTGAGTT
CGGCAACGGTAAGCGATGATTTCATGACAGAGCGTGAAATCAGCATTCAGCCCGAACGTGAGGGACTGTAA