Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1957885..1959521 Replicon chromosome
Accession NZ_CP061561
Organism Acinetobacter seifertii strain AS73

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag IC796_RS09520 Protein ID WP_151685621.1
Coordinates 1957885..1959216 (+) Length 444 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag IC796_RS09525 Protein ID WP_077163225.1
Coordinates 1959213..1959521 (+) Length 103 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC796_RS09505 1954557..1955795 + 1239 WP_151685627.1 TolC family protein -
IC796_RS09510 1955788..1956951 + 1164 WP_151685623.1 hypothetical protein -
IC796_RS09515 1957151..1957591 - 441 WP_049065179.1 HD domain-containing protein -
IC796_RS09520 1957885..1959216 + 1332 WP_151685621.1 HipA domain-containing protein Toxin
IC796_RS09525 1959213..1959521 + 309 WP_077163225.1 helix-turn-helix domain-containing protein Antitoxin
IC796_RS09530 1959950..1960177 - 228 WP_191036793.1 hypothetical protein -
IC796_RS09535 1960245..1960793 + 549 WP_151685619.1 TetR/AcrR family transcriptional regulator -
IC796_RS09540 1960985..1962681 + 1697 Protein_1855 AAA family ATPase -
IC796_RS09545 1962686..1964308 + 1623 WP_151685615.1 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(167-365)

Antitoxin

Cro/C1-type helix-turn-helix domain

(36-83)


Sequences

Toxin        


Download         Length: 444 a.a.        Molecular weight: 50975.93 Da        Isoelectric Point: 5.5003

>T172739 WP_151685621.1 NZ_CP061561:1957885-1959216 [Acinetobacter seifertii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYSDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKDDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQQVWIDTYQQQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETKQM
QLIEGTKYPSLWLPRFDTEWRGQSWHRHGLESVYSILNKSSGSHLNHFEVIEELCRLLTSIDSDFDASQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLATWCDPAVSLATLK
TLANNLLGLRQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Download         Length: 1332 bp

>T172739 NZ_CP079891:3906587-3906901 [Escherichia fergusonii]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCATTTCCCTTTGTTATCGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCATATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGGTAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACACGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACTTTGATTAAAGGAGCATTAGATTTTATGCTCGACGGGATTTAA

Antitoxin


Download         Length: 103 a.a.        Molecular weight: 11576.49 Da        Isoelectric Point: 9.9701

>AT172739 WP_077163225.1 NZ_CP061561:1959213-1959521 [Acinetobacter seifertii]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYATLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPSD

Download         Length: 309 bp

>AT172739 NZ_CP079891:3906351-3906584 [Escherichia fergusonii]
ATGACTGCAAAACGTACCACACAAAGTGTGACCGTCACCGTCGACCGTGAGTTAGTCAATCGCGCTCGTGATGCAGGCTT
AAATATGAGCGCCACCCTTACGGTTGCGCTCAATGCTGAACTTAAAAAACATGCAGCAACACGTTGGCGTGAAGAGAACG
CAGAAGCTATCGCTGCGTTAAATCAATTGGCTGATGAAACCGGATGTTTCTCTGATGAGTACCGGAGCTTCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References