Detailed information of TA system TA172738

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1843388..1845024
• Replicon: chromosome
• Accession: NZ_CP061550
• Organism: Acinetobacter seifertii strain AS79

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IC799_RS08605
• Protein ID: WP_191029117.1
• Coordinates: 1843388..1844719 (+)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: N8S5T2
• Locus tag: IC799_RS08610
• Protein ID: WP_004701524.1
• Coordinates: 1844716..1845024 (+)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IC799_RS08590	1840059..1841297	+	1239	WP_100192582.1	TolC family protein	-
IC799_RS08595	1841290..1842453	+	1164	WP_191029115.1	hypothetical protein	-
IC799_RS08600	1842653..1843093	-	441	WP_191029116.1	HD domain-containing protein	-
IC799_RS08605	1843388..1844719	+	1332	WP_191029117.1	HipA domain-containing protein	Toxin
IC799_RS08610	1844716..1845024	+	309	WP_004701524.1	helix-turn-helix domain-containing protein	Antitoxin
IC799_RS08615	1845750..1846310	+	561	WP_191029118.1	TetR/AcrR family transcriptional regulator	-
IC799_RS08620	1846619..1847389	+	771	WP_191029119.1	hypothetical protein	-
IC799_RS08625	1847499..1848374	-	876	WP_191029120.1	hypothetical protein	-
IC799_RS08630	1848562..1849392	+	831	WP_191029191.1	hypothetical protein	-
IC799_RS08635	1849515..1850009	+	495	WP_191029121.1	phage antirepressor KilAC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-365)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 50908.75 Da
• Isoelectric Point: 5.1291

>T172738 WP_191029117.1 NZ_CP061550:1843388-1844719 [Acinetobacter seifertii]
MKKLTIQALLNKNWLDIAELKLLEPKLGSASASELEYELNYAIQYSDRRDEHACSLSLPVQILIKHESNTWFGFLDDIVP
SGAARRYWVNYLDLQRLTHAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKDDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQQVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWRDQSWHRHGLESVYSILNKSSGSHLNHFEVIEELCTLLTSIGSDFDASQFVCEWLQRDLL
NIIFGNSDNHGRNTSFLKKSGKVYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLATWCDPAVSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLRRWELL

Nucleotide

• Length: 1332 bp

>T172738 NZ_CP079891:3862069-3862221 [Escherichia fergusonii]
ATGAAGCAGCATAAGGCGATAATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGTGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11590.52 Da
• Isoelectric Point: 9.9701

>AT172738 WP_004701524.1 NZ_CP061550:1844716-1845024 [Acinetobacter seifertii]
MNIKNQTQDRQQVLIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYATLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPSE

Nucleotide

• Length: 309 bp

>AT172738 NZ_CP079891:c3862020-3861963 [Escherichia fergusonii]
GTTCTGCATATAGGGGGCCTCGGGTTGATAGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Antitoxin

• AlphaFold DB: N8S5T2