Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 177642..178198 Replicon chromosome
Accession NZ_CP061539
Organism Rothia terrae strain KJZ-14

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IDM49_RS00845 Protein ID WP_190724690.1
Coordinates 177881..178198 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IDM49_RS00840 Protein ID WP_168614382.1
Coordinates 177642..177872 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM49_RS00820 173163..175277 - 2115 WP_168614378.1 phosphate acetyltransferase -
IDM49_RS00825 175597..176592 - 996 WP_190725503.1 MFS transporter -
IDM49_RS00830 176535..176975 - 441 WP_190724689.1 MFS transporter -
IDM49_RS00835 177214..177522 + 309 WP_168614381.1 thiamine-binding protein -
IDM49_RS00840 177642..177872 + 231 WP_168614382.1 ribbon-helix-helix protein, CopG family Antitoxin
IDM49_RS00845 177881..178198 + 318 WP_190724690.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IDM49_RS00850 178249..178893 - 645 WP_190724691.1 GNAT family N-acetyltransferase -
IDM49_RS00855 178940..179836 + 897 WP_190724692.1 fused MFS/spermidine synthase -
IDM49_RS00860 179935..180839 - 905 Protein_166 Ltp family lipoprotein -
IDM49_RS00865 181053..181472 - 420 WP_190724693.1 YchJ family protein -
IDM49_RS00870 181629..182396 + 768 WP_190724694.1 fructosamine kinase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-98)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11402.30 Da        Isoelectric Point: 7.1344

>T172735 WP_190724690.1 NZ_CP061539:177881-178198 [Rothia terrae]
MREICLVHLDKTRPALVLTREPTRFVMSKITIAPITSTVKGLSSEVLLGSQNGLNHECVASIDNILTVPASALGRTIGYL
TETQEKDLTRAVVLAFDLRVPLSEG

Download         Length: 318 bp

>T172735 NZ_CP079891:c2910873-2910721 [Escherichia fergusonii]
ATGCCGCAGAAATATAGATTACTTTCTTTAATAGTGATTTGTTTCACGCTTTTATTTTTCACCTGGATGATAAGAGATTC
ACTGTGTGAATTGCATATTAAACAGGAGAATTATGAGCTGGCGGCGTTTTTAGCCTGCAAATTGAAAGAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8269.11 Da        Isoelectric Point: 3.9129

>AT172735 WP_168614382.1 NZ_CP061539:177642-177872 [Rothia terrae]
MTTQIAVRLPDDLVEFLDSAVAHGEAPSRAAIVAEALEQERRKYAARADTQILQEQGTEDDLDDLVAWTASSAVID

Download         Length: 231 bp

>AT172735 NZ_CP079891:2910930-2910978 [Escherichia fergusonii]
GCATAGAGGGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References