Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 197788..198341 Replicon chromosome
Accession NZ_CP061538
Organism Rothia amarae strain KJZ-9

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag IDM48_RS00975 Protein ID WP_190617655.1
Coordinates 198021..198341 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A7H2BK67
Locus tag IDM48_RS00970 Protein ID WP_068173266.1
Coordinates 197788..198021 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM48_RS00955 193797..194936 - 1140 WP_145177420.1 acetate kinase -
IDM48_RS00960 195009..197117 - 2109 WP_190617651.1 phosphate acetyltransferase -
IDM48_RS00965 197336..197647 + 312 WP_190617653.1 thiamine-binding protein -
IDM48_RS00970 197788..198021 + 234 WP_068173266.1 hypothetical protein Antitoxin
IDM48_RS00975 198021..198341 + 321 WP_190617655.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IDM48_RS00980 198391..199026 - 636 WP_190617657.1 GNAT family N-acetyltransferase -
IDM48_RS00985 199228..200004 + 777 WP_190618553.1 fused MFS/spermidine synthase -
IDM48_RS00990 200001..200402 + 402 WP_190617659.1 hypothetical protein -
IDM48_RS00995 200429..200881 - 453 WP_190617661.1 SEC-C domain-containing protein -
IDM48_RS01000 200880..201371 + 492 WP_151146240.1 GNAT family N-acetyltransferase -
IDM48_RS01005 201465..202943 - 1479 WP_151146243.1 NCS2 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-93)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 11430.31 Da        Isoelectric Point: 6.9485

>T172734 WP_190617655.1 NZ_CP061538:198021-198341 [Rothia amarae]
MREICLVYVDKTRPALVLTREPTRFVMSKVTIAPITSTIKGLSSEVILDARNGLDHECAVSIDNTLTIPAAALGRTVGYL
TPAQEKQLARAVVFAFDLSVPLSGSE

Download         Length: 321 bp

>T172734 NZ_CP079891:c2881646-2881539 [Escherichia fergusonii]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8510.46 Da        Isoelectric Point: 4.3393

>AT172734 WP_068173266.1 NZ_CP061538:197788-198021 [Rothia amarae]
MTTQIAVRLPDDLVEFLDKTVSHGDAPSRAAIVTEALEAERRRQAAIHDVRLLGEAGTEDDLDDLVAWSARQKPWGD

Download         Length: 234 bp

>AT172734 NZ_CP079891:2881694-2881760 [Escherichia fergusonii]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7H2BK67

References