Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 3810300..3810895 Replicon chromosome
Accession NZ_CP061527
Organism Shigella dysenteriae strain HNCMB 20080

Toxin (Protein)


Gene name chpB Uniprot ID U9XNP6
Locus tag IC625_RS20265 Protein ID WP_000239577.1
Coordinates 3810300..3810650 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID A0A2X2I2M3
Locus tag IC625_RS20270 Protein ID WP_001223211.1
Coordinates 3810644..3810895 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC625_RS20245 3807031..3808116 - 1086 Protein_3954 cadaverine/lysine antiporter -
IC625_RS20250 3808175..3808869 + 695 WP_087786203.1 IS1-like element IS1N family transposase -
IC625_RS20255 3808883..3809383 - 501 Protein_3956 galactofuranose ABC transporter substrate-binding protein YtfQ -
IC625_RS20260 3809693..3810223 + 531 WP_000055075.1 inorganic diphosphatase -
IC625_RS20265 3810300..3810650 - 351 WP_000239577.1 endoribonuclease toxin ChpB Toxin
IC625_RS20270 3810644..3810895 - 252 WP_001223211.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IC625_RS20275 3811107..3811448 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IC625_RS20280 3811451..3815230 - 3780 WP_000060952.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

Antitoxin PemI-like

(1-83)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12492.40 Da        Isoelectric Point: 5.5572

>T172706 WP_000239577.1 NZ_CP061527:c3810650-3810300 [Shigella dysenteriae]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLHARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

>T172706 NZ_CP079884:1395558-1395956 [Escherichia fergusonii]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCCGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATTTATGGGGCAGAAAAAAGCCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGCTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACT
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCCGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCTGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9315.64 Da        Isoelectric Point: 4.4201

>AT172706 WP_001223211.1 NZ_CP061527:c3810895-3810644 [Shigella dysenteriae]
MRITIKRWGNSAGMVIPNVVMKELNLWPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT172706 NZ_CP079884:1395331-1395558 [Escherichia fergusonii]
ATGGAAACCACTGTATTTTTAAGTAATCGCAGTCAGGCTGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGACGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9XNP6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2I2M3

References