Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 214426..215180 Replicon chromosome
Accession NZ_CP061527
Organism Shigella dysenteriae strain HNCMB 20080

Toxin (Protein)


Gene name ataT Uniprot ID Q32AN3
Locus tag IC625_RS01045 Protein ID WP_000513068.1
Coordinates 214695..215180 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A2X2KZA0
Locus tag IC625_RS01040 Protein ID WP_000801913.1
Coordinates 214426..214704 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC625_RS01035 211660..214359 + 2700 WP_000907050.1 HTH-type transcriptional regulator MalT -
IC625_RS01040 214426..214704 + 279 WP_000801913.1 DUF1778 domain-containing protein Antitoxin
IC625_RS01045 214695..215180 + 486 WP_000513068.1 GNAT family N-acetyltransferase Toxin
IC625_RS01050 215230..216258 - 1029 WP_194947054.1 RNA 3'-terminal phosphate cyclase -
IC625_RS01055 216262..216762 - 501 Protein_198 RNA-splicing ligase RtcB -
IC625_RS01060 216762..217271 + 510 Protein_199 DNA-binding transcriptional regulator RtcR -
IC625_RS01065 217253..218011 - 759 WP_000815099.1 DeoR/GlpR family transcriptional regulator -
IC625_RS01070 218028..218858 - 831 WP_000928722.1 rhomboid family intramembrane serine protease GlpG -
IC625_RS01075 218903..219229 - 327 WP_000371932.1 thiosulfate sulfurtransferase GlpE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-143)

Antitoxin

Vibrio phage ICP1, Orf50

(2-92)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17631.53 Da        Isoelectric Point: 9.1197

>T172690 WP_000513068.1 NZ_CP061527:214695-215180 [Shigella dysenteriae]
MGITAPTPLTSEHNLADFCCSDHGMNEWLKKKALKNHSSGLSRVYVICIANTRQVIGYYCLSTGSIQRNLAPGAMRHNAP
ESLPVVVLGRLAIDQAWAGKGLGVALLKDAVYRTMSIAQQVGVRALIVHALDDSVRNFYLKYAFVPSPFQSLTLLYPITL
E

Download         Length: 486 bp

>T172690 NZ_CP079869:c4129496-4129128 [Mycobacterium sp. SMC-4]
ATGATTCTGGTGGACACCGCGGTGTGGATCGATCATCTTCACGCCGGAGAGTCCAGGCTGGTCGAGCACTTGGAACTGGA
TGGAGTCGGCTGCCATCCACTGGTGGTCGAGGAGTTGGCGCTCGGATCCATCGCACGCCGGAACATCGTGCTTGATCTTC
TTGCAAATCTGTGGCAGTTCCCGACCGCGCAGCATGAAGAGGTCCTGTATCTCGTCGAGCGACGGCAACTCTGGGGGCGC
GGACTGAGCGCAGTCGACGCCCATCTGATGGCGGCAGTCGCCATGGTCGAGGGTGCGCGACTATGGACCAGGGACAAACG
ATTGAAAGCTGCGTCGAGAGAAGTGGGCGTCGCGCTGTTCGATGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10449.00 Da        Isoelectric Point: 4.6336

>AT172690 WP_000801913.1 NZ_CP061527:214426-214704 [Shigella dysenteriae]
MKPESKEAPINIRAKASQRDLIDMAANLVAKSRTDFMLDAACREAQDILLDQRLFILDDEQYDAFLAALDAPITAERQVK
INALMNRKSPWE

Download         Length: 279 bp

>AT172690 NZ_CP079869:c4129687-4129493 [Mycobacterium sp. SMC-4]
TTGAGGACCACCGTCACCATCGACGACGATCTGCTGGCCAAAGCTGCCGAGCTCACGGGAGTGCACGAAAATGTTGCGCT
GCTCAAGCAAGGTCTGCAGACACTGATCCGGGTGGAAAGCGCTCGCCGTCTCGCCGCATTGGGCGGATCGGATTCCCAGG
CGAAGGCCGCGCCGCGGCGACGTGCGTCGGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A090ND96

Antitoxin

Source ID Structure
AlphaFold DB A0A2X2KZA0

References