172689

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 5666..6254 Replicon plasmid pCFSAN093705
Accession NZ_CP061526
Organism Acinetobacter baumannii strain CFSAN093705

Toxin (Protein)


Gene name brnT Uniprot ID A0A0J8TIH5
Locus tag FQZ18_RS19320 Protein ID WP_000438827.1
Coordinates 5666..5953 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9M5I3
Locus tag FQZ18_RS19325 Protein ID WP_001983304.1
Coordinates 5940..6254 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQZ18_RS19290 944..1519 + 576 WP_001096611.1 helix-turn-helix domain-containing protein -
FQZ18_RS19295 1541..1684 + 144 WP_000734097.1 hypothetical protein -
FQZ18_RS19300 1991..2266 + 276 WP_001133626.1 metal/formaldehyde-sensitive transcriptional repressor -
FQZ18_RS19305 2288..3397 + 1110 WP_000842148.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
FQZ18_RS19310 3450..3848 + 399 WP_000235176.1 VOC family protein -
FQZ18_RS19315 4322..5155 + 834 WP_000439570.1 S-formylglutathione hydrolase -
FQZ18_RS19320 5666..5953 + 288 WP_000438827.1 BrnT family toxin Toxin
FQZ18_RS19325 5940..6254 + 315 WP_001983304.1 BrnA antitoxin family protein Antitoxin
FQZ18_RS19330 6382..8793 + 2412 WP_000932953.1 TonB-dependent receptor ZnuD2 -
FQZ18_RS19335 9098..9559 + 462 WP_000761346.1 DIP1984 family protein -
FQZ18_RS19340 9880..10413 - 534 WP_000965055.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..14639 14639


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11329.75 Da        Isoelectric Point: 5.6762

>T172689 WP_000438827.1 NZ_CP061526:5666-5953 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRYTNGEERWQTIGRVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNKYEHG

Download         Length: 288 bp

>T172689 NZ_CP079867:90347-90649 [Mycobacterium sp. SMC-8]
GTGATCGCTCCCGGGGACATCGCCCCGCGTCGCGATACCAGCCATGAGGTCTATGTTGTCGTGCTATCCAACTCGATTCA
CCTGGCGGCCGATACCGGACGAGTCATCGCCTGCCCCTTTATTCCGGGCAAAATTCCCGACGCCGCAATGGCGTTCGTCG
TTCGAGTCGGACAACCCGAAGGCGTGGCGCTGCCCGAACTTGTTCAGTGGCTTCCCGCAGCAGCGCTGGACGAGCCGATC
GGCAACATCGGCGCGAATGCGCTCCGTGACACAGCGTCTCTCGTGACAGCCCTCGTCACCTGA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12208.84 Da        Isoelectric Point: 7.2026

>AT172689 WP_001983304.1 NZ_CP061526:5940-6254 [Acinetobacter baumannii]
MSMVRYSHKELNEKFGEKQDAEIQRLLAKGTVPDDQLDLSDIPEITDWSNAVRQNQFYRPVKQQTSIRLDADVLAWFKAQ
GKGYQTRMNEILRDAMLKELKNHQ

Download         Length: 315 bp

>AT172689 NZ_CP079867:90123-90350 [Mycobacterium sp. SMC-8]
ATGGCCAAAGACAAGGTGTCGATCACACTGGATCAGGATGTGCTAGCAGCGGCAGATGCAGACGCCAAAGCGGCTGGGCT
CAACCGATCCGAGTTAGTTGAGCAGGCATTGCGCCACGAACACCTCCGGATCGCTCTGAAAAGCTACATGACGACAACCG
TCCCCGCCCTGGACATCGACGACTACGCACAGAAGATCTACCAGGCGAATCGGGCCTCGGGCCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J8TIH5

Antitoxin

Source ID Structure
AlphaFold DB N9M5I3

References