Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 1088647..1089298 | Replicon | chromosome |
| Accession | NZ_CP061525 | ||
| Organism | Acinetobacter baumannii strain CFSAN093705 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | S3TWT7 |
| Locus tag | FQZ18_RS05350 | Protein ID | WP_000838146.1 |
| Coordinates | 1088647..1088829 (+) | Length | 61 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | A0A0J1AAF8 |
| Locus tag | FQZ18_RS05355 | Protein ID | WP_000966689.1 |
| Coordinates | 1088894..1089298 (+) | Length | 135 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FQZ18_RS05305 | 1083904..1084569 | + | 666 | WP_000767881.1 | stress-responsive nuclear envelope protein | - |
| FQZ18_RS05310 | 1084574..1084963 | + | 390 | WP_000008492.1 | hypothetical protein | - |
| FQZ18_RS05315 | 1084920..1085333 | + | 414 | WP_001197735.1 | hypothetical protein | - |
| FQZ18_RS05320 | 1085342..1085746 | + | 405 | WP_000248324.1 | hypothetical protein | - |
| FQZ18_RS05325 | 1085718..1086086 | + | 369 | WP_000539752.1 | hypothetical protein | - |
| FQZ18_RS05330 | 1086088..1086486 | + | 399 | WP_001132270.1 | hypothetical protein | - |
| FQZ18_RS05335 | 1086488..1086700 | + | 213 | WP_000121166.1 | hypothetical protein | - |
| FQZ18_RS05340 | 1086808..1087737 | + | 930 | WP_000094300.1 | hypothetical protein | - |
| FQZ18_RS05345 | 1087782..1088315 | + | 534 | WP_001185622.1 | hypothetical protein | - |
| FQZ18_RS05350 | 1088647..1088829 | + | 183 | WP_000838146.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| FQZ18_RS05355 | 1088894..1089298 | + | 405 | WP_000966689.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| FQZ18_RS05360 | 1089379..1089780 | + | 402 | WP_000720591.1 | hypothetical protein | - |
| FQZ18_RS05365 | 1089841..1093806 | + | 3966 | WP_000191304.1 | tape measure protein | - |
| FQZ18_RS05370 | 1093924..1094265 | + | 342 | WP_001281459.1 | phage tail protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1058254..1112869 | 54615 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 61 a.a. Molecular weight: 6695.84 Da Isoelectric Point: 10.5523
>T172688 WP_000838146.1 NZ_CP061525:1088647-1088829 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN
Download Length: 183 bp
>T172688 NZ_CP079865:c2557352-2556771 [Mycobacterium sp. SMC-8]
GTGAAGCGCCTCGACCTCGTCGTCGGATCCAACGGTGCCGGCAAATCGACGTTCATCGAGCTGACCCTCGCGCCGCTGCT
GCCCCTCAGCATGTACGTGAACGCCGACGAGATCGCCAAGCGGCGCTGGCCCGAGGACCCTGCCGGACACAGCTACGAGG
CGGCGCGGATTGCCGCGGACACTCGCGCACGGCTCATCGAACGTGGCGAGTCCTTTATCGCCGAGACAGTTTTCTCACAC
CCCTCAAAACTGGAACTGCTCGATGCCGCCCACGCGGCGGATTACACAGTGATCCTGCACGCGGTGCTGATCCCGGAAGA
TCTTGCCGTGCTCCGCGTCCGACACCGAGTCCAGGCCGGGGGTCACGACGTGCCCGAATCCAAAATCCGCCAGCGCTATC
AACGGCTTTGGGACCTGGTCGCCACCGCCGCCAACCGCGCGGACGAAGCAACGTTCTACGACAACAGCACGACTCGCGGT
CCGCGCATCGTCGCTCAGCTCGCCGCTGGAATCGCAGTGGGTTCAGCCACGTGGCCGTCGTGGACTCCGGCCCCACTCGC
CCACCGCTGGGCAGGCAGGTGA
GTGAAGCGCCTCGACCTCGTCGTCGGATCCAACGGTGCCGGCAAATCGACGTTCATCGAGCTGACCCTCGCGCCGCTGCT
GCCCCTCAGCATGTACGTGAACGCCGACGAGATCGCCAAGCGGCGCTGGCCCGAGGACCCTGCCGGACACAGCTACGAGG
CGGCGCGGATTGCCGCGGACACTCGCGCACGGCTCATCGAACGTGGCGAGTCCTTTATCGCCGAGACAGTTTTCTCACAC
CCCTCAAAACTGGAACTGCTCGATGCCGCCCACGCGGCGGATTACACAGTGATCCTGCACGCGGTGCTGATCCCGGAAGA
TCTTGCCGTGCTCCGCGTCCGACACCGAGTCCAGGCCGGGGGTCACGACGTGCCCGAATCCAAAATCCGCCAGCGCTATC
AACGGCTTTGGGACCTGGTCGCCACCGCCGCCAACCGCGCGGACGAAGCAACGTTCTACGACAACAGCACGACTCGCGGT
CCGCGCATCGTCGCTCAGCTCGCCGCTGGAATCGCAGTGGGTTCAGCCACGTGGCCGTCGTGGACTCCGGCCCCACTCGC
CCACCGCTGGGCAGGCAGGTGA
Antitoxin
Download Length: 135 a.a. Molecular weight: 14769.78 Da Isoelectric Point: 4.5000
>AT172688 WP_000966689.1 NZ_CP061525:1088894-1089298 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA
Download Length: 405 bp
>AT172688 NZ_CP079865:c2557780-2557391 [Mycobacterium sp. SMC-8]
ATGTCCGACACCACTGATCGAGTGACCCGGGTCGCCGCGGATCTGATGGACAGCGCCGCCACCGAAGGTGCACGTCAGAG
CAGATCGGCGAAACAGCAGCTGGACCACTGGGCGCGGGTAGGGCGAGCGGTTTCCAGTCAGCACAGCGTTGCCCGCCGCA
GGGTGGAAGCCGCCCTTGCGGGCAACATTCATCTTCGGGAGCTCACCGATGAAGAAGGAGTCGTGTTCAACGCTGAGATC
TCCGCGGCTGTCCAGGAACGCCTTGCGCGCGCCGACTACGGCGCAGTGCTGGCCGCGCGGGGAATCACCACGGTGGCGCT
CGACGATGACGGCGAGATCGTGCAGTACGCGCCTGACGGCAGTTCGGTACGGCTGCACCGCGGGGCATGA
ATGTCCGACACCACTGATCGAGTGACCCGGGTCGCCGCGGATCTGATGGACAGCGCCGCCACCGAAGGTGCACGTCAGAG
CAGATCGGCGAAACAGCAGCTGGACCACTGGGCGCGGGTAGGGCGAGCGGTTTCCAGTCAGCACAGCGTTGCCCGCCGCA
GGGTGGAAGCCGCCCTTGCGGGCAACATTCATCTTCGGGAGCTCACCGATGAAGAAGGAGTCGTGTTCAACGCTGAGATC
TCCGCGGCTGTCCAGGAACGCCTTGCGCGCGCCGACTACGGCGCAGTGCTGGCCGCGCGGGGAATCACCACGGTGGCGCT
CGACGATGACGGCGAGATCGTGCAGTACGCGCCTGACGGCAGTTCGGTACGGCTGCACCGCGGGGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | S3TWT7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0J1AAF8 |