Detailed information of TA system TA172686

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1252870..1253549
• Replicon: chromosome
• Accession: NZ_CP061523
• Organism: Acinetobacter baumannii strain CFSAN093706

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FQZ16_RS06045
• Protein ID: WP_000838146.1
• Coordinates: 1252870..1253052 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FQZ16_RS06050
• Protein ID: WP_000966688.1
• Coordinates: 1253145..1253549 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQZ16_RS06010	1247890..1248333	+	444	WP_002016455.1	hypothetical protein	-
FQZ16_RS06015	1248335..1248553	+	219	WP_001277696.1	hypothetical protein	-
FQZ16_RS06020	1248662..1249183	+	522	WP_000749909.1	SH3 domain-containing protein	-
FQZ16_RS06025	1249280..1249633	+	354	WP_000064593.1	hypothetical protein	-
FQZ16_RS06030	1249633..1250988	+	1356	WP_000002415.1	hypothetical protein	-
FQZ16_RS06035	1251041..1251958	+	918	WP_000094253.1	hypothetical protein	-
FQZ16_RS06040	1252029..1252544	+	516	WP_024616020.1	hypothetical protein	-
FQZ16_RS06045	1252870..1253052	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FQZ16_RS06050	1253145..1253549	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FQZ16_RS06055	1253649..1254173	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
FQZ16_RS06060	1254238..1254621	+	384	WP_000725052.1	hypothetical protein	-
FQZ16_RS06065	1254683..1255429	+	747	WP_000599537.1	hypothetical protein	-
FQZ16_RS06070	1255515..1256006	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
FQZ16_RS06075	1256049..1256315	-	267	WP_000774879.1	hypothetical protein	-
FQZ16_RS06080	1256465..1257400	+	936	WP_000254125.1	ORF6N domain-containing protein	-
FQZ16_RS06085	1257741..1258256	+	516	WP_001056868.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1222810..1274753	51943

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172686 WP_000838146.1 NZ_CP061523:1252870-1253052 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172686 NZ_CP079865:c170255-169695 [Mycobacterium sp. SMC-8]
GTGAGCGATGCGCTCGACGAGGACCTGGTGCAGCGCATCGACGCGCGCGGCACCAACCGGTGGTCGGGCACGTGCGCTCG
CTACACCGGCGCCCACCGTGACCCCTTGTCGGGGGAAGGGGCGCGCAGATTCGGCGGAAGGTGGAACCCTGCCGGACTCT
TCTCGGCGATCTATCTGGCCGACTCCACGCAAGCGTGCATGGTCGAAGTAGAACGCGCCGCGCAGGCGGCGTCGACGACC
CCGGAGAAGATGCTCGAAGCTTCGTATCGACTGCACACCATCGAGGCCACCGACCTGGCCGTCCTGGATCTCATCACCTC
TGACGCCCGCGAAGCGGTGGGGCTCGAGGACGACGACATCTATGGCGACGACTGGTCGGCGTGCCAAGCGGTGGGCCATG
CCGCATGGTTCCTGCATGTGCAAGGCGTACTGGTGCCTGCCGCCGGGGGAATTGGCCTGGTCATCACCGCCTACGAACAA
CGGACCCGCCCCGGTCAGCTCCACGTCAGCCACAGCGAGGATCTGACACCTATCCGCTACGGAGAACTGCGGCACCCTTA
A

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172686 WP_000966688.1 NZ_CP061523:1253145-1253549 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172686 NZ_CP079865:c170593-170252 [Mycobacterium sp. SMC-8]
ATGGGAGCTAACGCGCTCGCCTCGACCGTGTCGAGTGCGATCGAGCGCTTGGGATTGACCTACGAAGAGGTCGGCGACAT
CGTCGACGCGTCGGCGCGCTCGGTGGCGCGCTGGACCTCAGGACAGGTCGTTCCACAACGACTCAACAAACAACGACTCA
TCGAACTGGCCTACGTCGCCGACGCGCTGGCCGAAGTGCTTCCCCGGGACCAGGCCAACGTCTGGATGTTCTCCCCGAAT
CGATTACTGGCCCACGCCAAGCCCGCCGACCTGGTGCGTGACGGCGAGTACCAGCGCGTCTTGGCCCTCATCGACGCCAT
GGCCGAAGGGATCTTCGTGTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6