Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1068333..1068984 Replicon chromosome
Accession NZ_CP061521
Organism Acinetobacter baumannii strain CFSAN093707

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag FQZ15_RS05250 Protein ID WP_000838146.1
Coordinates 1068333..1068515 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag FQZ15_RS05255 Protein ID WP_000966689.1
Coordinates 1068580..1068984 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQZ15_RS05205 1063590..1064255 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
FQZ15_RS05210 1064260..1064649 + 390 WP_000008492.1 hypothetical protein -
FQZ15_RS05215 1064606..1065019 + 414 WP_001197735.1 hypothetical protein -
FQZ15_RS05220 1065028..1065432 + 405 WP_000248324.1 hypothetical protein -
FQZ15_RS05225 1065404..1065772 + 369 WP_000539752.1 hypothetical protein -
FQZ15_RS05230 1065774..1066172 + 399 WP_001132270.1 hypothetical protein -
FQZ15_RS05235 1066174..1066386 + 213 WP_000121166.1 hypothetical protein -
FQZ15_RS05240 1066494..1067423 + 930 WP_000094300.1 hypothetical protein -
FQZ15_RS05245 1067468..1068001 + 534 WP_001185622.1 hypothetical protein -
FQZ15_RS05250 1068333..1068515 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
FQZ15_RS05255 1068580..1068984 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FQZ15_RS05260 1069065..1069466 + 402 WP_000720591.1 hypothetical protein -
FQZ15_RS05265 1069527..1073492 + 3966 WP_000191304.1 tape measure protein -
FQZ15_RS05270 1073610..1073951 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1033959..1092555 58596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T172683 WP_000838146.1 NZ_CP061521:1068333-1068515 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T172683 NZ_CP079863:c2027442-2027161 [Mycobacterium sp. SMC-2]
ATGGCGGCGGTTGCCGGTGCTATCGACCTGCTGGAGCCGGAGGGGCCGACATTGGGCCGGCCGATCGTCGACAAGGTGAA
CGGCTCGAAGTTTCACAGCATGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGCGTCCTGTTCATCTTCGACCCGGCAC
GGCAGGCGATCCTGCTGCTGGGCGGCAACAAGGCAGGCGACTGGAAGCGCTGGTACGACAGGAACATTCCAATCGCGGAC
GCGCGCTTCGAGAGCTGGCTGGCGACCGAGCACGGAGGGTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT172683 WP_000966689.1 NZ_CP061521:1068580-1068984 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT172683 NZ_CP079863:c2027161-2026832 [Mycobacterium sp. SMC-2]
ATGACCATGGCGCGCAATTGGCGAGACATTCGCGCCGACGCGATCGCGCAGGGTGCACTGGATACCAATCGGGCCAGTGC
GGCGCGCGAGGAGATGCGTGAGGCCGTCCAGGCGCACCGTCTGGCCGAGATCCGCAAAGCGCTGGGCCACTCCCGCCAAG
CCGACGTTGCGGCCCTGATGGGTGTCTCACAGGCCCGCGTTTCGAAGCTTGAGAGCGGGGACTTGTCGCACACCGAGCTG
GGCACGCTCCAGGCGTACGTCGCCGCGCTGGGCGGGCAGCTCCGCGTCGTCGCCGAATTCGGCGACGACACCGTCGAACT
GACGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References