Detailed information of TA system TA172680

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1305357..1306036
• Replicon: chromosome
• Accession: NZ_CP061519
• Organism: Acinetobacter baumannii strain CFSAN093708

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FQZ17_RS06390
• Protein ID: WP_000838146.1
• Coordinates: 1305357..1305539 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FQZ17_RS06395
• Protein ID: WP_000966688.1
• Coordinates: 1305632..1306036 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQZ17_RS06355	1300377..1300820	+	444	WP_002016455.1	hypothetical protein	-
FQZ17_RS06360	1300822..1301040	+	219	WP_001277696.1	hypothetical protein	-
FQZ17_RS06365	1301149..1301670	+	522	WP_000749909.1	SH3 domain-containing protein	-
FQZ17_RS06370	1301767..1302120	+	354	WP_000064593.1	hypothetical protein	-
FQZ17_RS06375	1302120..1303475	+	1356	WP_000002415.1	hypothetical protein	-
FQZ17_RS06380	1303528..1304445	+	918	WP_000094253.1	hypothetical protein	-
FQZ17_RS06385	1304516..1305031	+	516	WP_024616020.1	hypothetical protein	-
FQZ17_RS06390	1305357..1305539	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FQZ17_RS06395	1305632..1306036	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FQZ17_RS06400	1306136..1306660	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
FQZ17_RS06405	1306725..1307108	+	384	WP_000725052.1	hypothetical protein	-
FQZ17_RS06410	1307170..1307916	+	747	WP_000599537.1	hypothetical protein	-
FQZ17_RS06415	1308002..1308493	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
FQZ17_RS06420	1308536..1308802	-	267	WP_000774879.1	hypothetical protein	-
FQZ17_RS06425	1308952..1309887	+	936	WP_000254125.1	ORF6N domain-containing protein	-
FQZ17_RS06430	1310228..1310743	+	516	WP_001056868.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1275297..1324950	49653

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172680 WP_000838146.1 NZ_CP061519:1305357-1305539 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172680 NZ_CP061519:1305357-1305539 [Acinetobacter baumannii]
GTGAAAAGTCTGGATTTAATCAAAATGATTGAAGCAGATGGTTGGTATGAGGTTAGGGTTTCAGGAAGTCATCATCACTT
TAAACACCCAACCAAAAAGGGGTTAGTTACAATCCCACATCCTAAAAAGGATTTACCAAACGGAACTGTTAAAAGCATTT
TGAAACAAGCGGGTCTAAATTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172680 WP_000966688.1 NZ_CP061519:1305632-1306036 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172680 NZ_CP061519:1305632-1306036 [Acinetobacter baumannii]
ATGTTATATCCAATTGCAATTGAACGAGGATCAGATACTGAGGCATTTGGTGTCACTGTTCCTGATATTCCAGGTTGTTT
TAGTGCTGGTGACACACTTGAAGAAGCTATTGAGAATGTTAAAGAAGCTATTTCAGGCCATTTAGAAATATTGGCTGAAG
ATGGTGAGGAAATCCCATTAGCTTCCGAACTAGTTAAATTTGTCGATGATCCTGAATATAAAGGAATGATCTGGGCGGTT
ACCGAAGTTGATGTTAGTCGTTATCTGGGTAAACCAGAAAAAATCAATGTTACTTTACCAAGCCGTTTGATTCGTAAAAT
TGATGAGAATGTAGGTAAAGGTAAGAGATATACTACTCGATCGGCTTTCTTGGCTGCTGGTGCTGAAAAACTTTTACATG
CATAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6