Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1069158..1069809 Replicon chromosome
Accession NZ_CP061519
Organism Acinetobacter baumannii strain CFSAN093708

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag FQZ17_RS05265 Protein ID WP_000838146.1
Coordinates 1069158..1069340 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag FQZ17_RS05270 Protein ID WP_000966689.1
Coordinates 1069405..1069809 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FQZ17_RS05220 1064415..1065080 + 666 WP_000767881.1 stress-responsive nuclear envelope protein -
FQZ17_RS05225 1065085..1065474 + 390 WP_000008492.1 hypothetical protein -
FQZ17_RS05230 1065431..1065844 + 414 WP_001197735.1 hypothetical protein -
FQZ17_RS05235 1065853..1066257 + 405 WP_000248324.1 hypothetical protein -
FQZ17_RS05240 1066229..1066597 + 369 WP_000539752.1 hypothetical protein -
FQZ17_RS05245 1066599..1066997 + 399 WP_001132270.1 hypothetical protein -
FQZ17_RS05250 1066999..1067211 + 213 WP_000121166.1 hypothetical protein -
FQZ17_RS05255 1067319..1068248 + 930 WP_000094300.1 hypothetical protein -
FQZ17_RS05260 1068293..1068826 + 534 WP_001185622.1 hypothetical protein -
FQZ17_RS05265 1069158..1069340 + 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
FQZ17_RS05270 1069405..1069809 + 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FQZ17_RS05275 1069890..1070291 + 402 WP_000720591.1 hypothetical protein -
FQZ17_RS05280 1070352..1074317 + 3966 WP_000191304.1 tape measure protein -
FQZ17_RS05285 1074435..1074776 + 342 WP_001281459.1 phage tail protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1038765..1093380 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T172679 WP_000838146.1 NZ_CP061519:1069158-1069340 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T172679 NZ_CP079862:5220731-5220991 [Frankia sp. ArI3]
GTGAAGCTGACCTGGACGGACCACGCCTGGGACGACTACCTGTACTGGCAGGGCCAGGACCGCAGGACACTGAAGCGCAT
CAACGCCCTGATCGCGGACATCGGACGCGATCCGGAGGGGCAGGGGATCGGCAAGCCCGAACTGCTGCGCAACAACCTCG
CCGGCCTGCGCTCGCGGCGGATCGATGACGAACACCGCCTGGTCTATGCGGTCGAGCCCGGCCAGATCACGATCATCGCC
TGCCGCTACCACTACCAGTAG

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT172679 WP_000966689.1 NZ_CP061519:1069405-1069809 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT172679 NZ_CP079862:5220477-5220734 [Frankia sp. ArI3]
ATGGTTTCGGCGATCAGTGCCAGTGAGGCACGTAAGACGCTGTTTCCGCTGATCGAGCAGGTCAACACCGATCACACACC
GGTAGAGATCGTCTCGAAGCGGGGGAACGCGGTCCTGGTGAGCAAGGAGGACTGGGACGCCATCGTGGAGACCAACTACC
TGCTGCGCACGCCCGCGAACGCGCGGCGCCTGATGGAAAGCGTGGAGCAGTGGCGTACGGGCGGCGCGGTCGAGCGTCCG
GTGGGCCCTGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References