Detailed information of TA system TA172678

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 540497..541176
• Replicon: chromosome
• Accession: NZ_CP061519
• Organism: Acinetobacter baumannii strain CFSAN093708

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FQZ17_RS02740
• Protein ID: WP_000838146.1
• Coordinates: 540497..540679 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FQZ17_RS02745
• Protein ID: WP_000966688.1
• Coordinates: 540772..541176 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FQZ17_RS02705	535517..535960	+	444	WP_002016455.1	hypothetical protein	-
FQZ17_RS02710	535962..536180	+	219	WP_001277696.1	hypothetical protein	-
FQZ17_RS02715	536289..536810	+	522	WP_000749909.1	SH3 domain-containing protein	-
FQZ17_RS02720	536907..537260	+	354	WP_000064593.1	hypothetical protein	-
FQZ17_RS02725	537260..538615	+	1356	WP_000002415.1	hypothetical protein	-
FQZ17_RS02730	538668..539585	+	918	WP_000094253.1	hypothetical protein	-
FQZ17_RS02735	539656..540171	+	516	WP_024616020.1	hypothetical protein	-
FQZ17_RS02740	540497..540679	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FQZ17_RS02745	540772..541176	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FQZ17_RS02750	541275..541955	+	681	WP_000721572.1	hypothetical protein	-
FQZ17_RS02755	541957..542220	+	264	WP_001275792.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	507831..560004	52173

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172678 WP_000838146.1 NZ_CP061519:540497-540679 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172678 NZ_CP079862:5220477-5220734 [Frankia sp. ArI3]
ATGGTTTCGGCGATCAGTGCCAGTGAGGCACGTAAGACGCTGTTTCCGCTGATCGAGCAGGTCAACACCGATCACACACC
GGTAGAGATCGTCTCGAAGCGGGGGAACGCGGTCCTGGTGAGCAAGGAGGACTGGGACGCCATCGTGGAGACCAACTACC
TGCTGCGCACGCCCGCGAACGCGCGGCGCCTGATGGAAAGCGTGGAGCAGTGGCGTACGGGCGGCGCGGTCGAGCGTCCG
GTGGGCCCTGACGAGTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172678 WP_000966688.1 NZ_CP061519:540772-541176 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172678 NZ_CP079862:5220731-5220991 [Frankia sp. ArI3]
GTGAAGCTGACCTGGACGGACCACGCCTGGGACGACTACCTGTACTGGCAGGGCCAGGACCGCAGGACACTGAAGCGCAT
CAACGCCCTGATCGCGGACATCGGACGCGATCCGGAGGGGCAGGGGATCGGCAAGCCCGAACTGCTGCGCAACAACCTCG
CCGGCCTGCGCTCGCGGCGGATCGATGACGAACACCGCCTGGTCTATGCGGTCGAGCCCGGCCAGATCACGATCATCGCC
TGCCGCTACCACTACCAGTAG

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6