Detailed information of TA system TA172676

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1308801..1309480
• Replicon: chromosome
• Accession: NZ_CP061517
• Organism: Acinetobacter baumannii strain CFSAN093709

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FRO58_RS06385
• Protein ID: WP_000838146.1
• Coordinates: 1308801..1308983 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FRO58_RS06390
• Protein ID: WP_000966688.1
• Coordinates: 1309076..1309480 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRO58_RS06350	1303821..1304264	+	444	WP_002016455.1	hypothetical protein	-
FRO58_RS06355	1304266..1304484	+	219	WP_001277696.1	hypothetical protein	-
FRO58_RS06360	1304593..1305114	+	522	WP_000749909.1	SH3 domain-containing protein	-
FRO58_RS06365	1305211..1305564	+	354	WP_000064593.1	hypothetical protein	-
FRO58_RS06370	1305564..1306919	+	1356	WP_000002415.1	hypothetical protein	-
FRO58_RS06375	1306972..1307889	+	918	WP_000094253.1	hypothetical protein	-
FRO58_RS06380	1307960..1308475	+	516	WP_024616020.1	hypothetical protein	-
FRO58_RS06385	1308801..1308983	+	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FRO58_RS06390	1309076..1309480	+	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FRO58_RS06395	1309580..1310104	+	525	WP_000721574.1	DUF4468 domain-containing protein	-
FRO58_RS06400	1310169..1310552	+	384	WP_000725052.1	hypothetical protein	-
FRO58_RS06405	1310614..1311360	+	747	WP_000599537.1	hypothetical protein	-
FRO58_RS06410	1311446..1311937	+	492	WP_000755583.1	DUF4468 domain-containing protein	-
FRO58_RS06415	1311980..1312246	-	267	WP_000774879.1	hypothetical protein	-
FRO58_RS06420	1312396..1313331	+	936	WP_000254125.1	ORF6N domain-containing protein	-
FRO58_RS06425	1313672..1314187	+	516	WP_001056868.1	Rha family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1300858..1328394	27536

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172676 WP_000838146.1 NZ_CP061517:1308801-1308983 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172676 NZ_CP079862:134339-134593 [Frankia sp. ArI3]
GTGAAGCTCGTCTGGGATGAGAACGCGTGGCAGGACTATCTCTGGTGGCGGACGGAGAACCGCAAGATCCTCAAGCGCAT
CAACGTCCTGATCCAGGACATAGCCCGGAATGGCAACGACGGCATCGGCAAACCCGAACCCCTCAAGCATGGCTTCCAGG
GCTACTGGTCCCGCCGCATCAACGACGAACACCGACTGATCTACAAGATCAGCGACGATCAGATCCGCATCGCCCAGTGC
CGGTACCACTACTGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172676 WP_000966688.1 NZ_CP061517:1309076-1309480 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172676 NZ_CP079862:134100-134342 [Frankia sp. ArI3]
ATGAGCTACTCAGAGTCACGTGCACGCTATGCCGAAGTTCTGACCGCGGTGGCAGATGACCGGGAGGAGGTCGTCATCAC
CCGGGCCGGACATGAGCCGGTCGTCATCGTCTCCCTGGATGACTACCAGTCCCTCAAGGAGACGGCCTACCTTCTGCGCA
GTCCCGAGAACGCCCGCCGGCTCCTGGCCGCCATCGACCGCCTCGAAAGCGGTGCCGGCACCGTACGCGATCTCGTCGAG
TGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6