Detailed information of TA system TA172675

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1225013..1225692
• Replicon: chromosome
• Accession: NZ_CP061517
• Organism: Acinetobacter baumannii strain CFSAN093709

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: S3TWT7
• Locus tag: FRO58_RS05870
• Protein ID: WP_000838146.1
• Coordinates: 1225510..1225692 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: N9L2H6
• Locus tag: FRO58_RS05865
• Protein ID: WP_000966688.1
• Coordinates: 1225013..1225417 (-)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FRO58_RS05855	1223969..1224232	-	264	WP_001275792.1	hypothetical protein	-
FRO58_RS05860	1224234..1224914	-	681	WP_000721572.1	hypothetical protein	-
FRO58_RS05865	1225013..1225417	-	405	WP_000966688.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
FRO58_RS05870	1225510..1225692	-	183	WP_000838146.1	type II toxin-antitoxin system HicA family toxin	Toxin
FRO58_RS05875	1226018..1226533	-	516	WP_024616020.1	hypothetical protein	-
FRO58_RS05880	1226604..1227521	-	918	WP_000094253.1	hypothetical protein	-
FRO58_RS05885	1227574..1228929	-	1356	WP_000002415.1	hypothetical protein	-
FRO58_RS05890	1228929..1229282	-	354	WP_000064593.1	hypothetical protein	-
FRO58_RS05895	1229379..1229900	-	522	WP_000749909.1	SH3 domain-containing protein	-
FRO58_RS05900	1230009..1230227	-	219	WP_001277696.1	hypothetical protein	-
FRO58_RS05905	1230229..1230672	-	444	WP_002016455.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1206185..1255750	49565

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-126)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6695.84 Da
• Isoelectric Point: 10.5523

>T172675 WP_000838146.1 NZ_CP061517:c1225692-1225510 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Nucleotide

• Length: 183 bp

>T172675 NZ_CP079862:134100-134342 [Frankia sp. ArI3]
ATGAGCTACTCAGAGTCACGTGCACGCTATGCCGAAGTTCTGACCGCGGTGGCAGATGACCGGGAGGAGGTCGTCATCAC
CCGGGCCGGACATGAGCCGGTCGTCATCGTCTCCCTGGATGACTACCAGTCCCTCAAGGAGACGGCCTACCTTCTGCGCA
GTCCCGAGAACGCCCGCCGGCTCCTGGCCGCCATCGACCGCCTCGAAAGCGGTGCCGGCACCGTACGCGATCTCGTCGAG
TGA

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 14647.69 Da
• Isoelectric Point: 4.4328

>AT172675 WP_000966688.1 NZ_CP061517:c1225417-1225013 [Acinetobacter baumannii]
MLYPIAIERGSDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASELVKFVDDPEYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Nucleotide

• Length: 405 bp

>AT172675 NZ_CP079862:134339-134593 [Frankia sp. ArI3]
GTGAAGCTCGTCTGGGATGAGAACGCGTGGCAGGACTATCTCTGGTGGCGGACGGAGAACCGCAAGATCCTCAAGCGCAT
CAACGTCCTGATCCAGGACATAGCCCGGAATGGCAACGACGGCATCGGCAAACCCGAACCCCTCAAGCATGGCTTCCAGG
GCTACTGGTCCCGCCGCATCAACGACGAACACCGACTGATCTACAAGATCAGCGACGATCAGATCCGCATCGCCCAGTGC
CGGTACCACTACTGA

Structures

Toxin

• AlphaFold DB: S3TWT7

Antitoxin

• AlphaFold DB: N9L2H6