Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 696052..696703 Replicon chromosome
Accession NZ_CP061517
Organism Acinetobacter baumannii strain CFSAN093709

Toxin (Protein)


Gene name hicA Uniprot ID S3TWT7
Locus tag FRO58_RS03360 Protein ID WP_000838146.1
Coordinates 696521..696703 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1AAF8
Locus tag FRO58_RS03355 Protein ID WP_000966689.1
Coordinates 696052..696456 (-) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FRO58_RS03340 691085..691426 - 342 WP_001281459.1 phage tail protein -
FRO58_RS03345 691544..695509 - 3966 WP_000191304.1 tape measure protein -
FRO58_RS03350 695570..695971 - 402 WP_000720591.1 hypothetical protein -
FRO58_RS03355 696052..696456 - 405 WP_000966689.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
FRO58_RS03360 696521..696703 - 183 WP_000838146.1 type II toxin-antitoxin system HicA family toxin Toxin
FRO58_RS03365 697035..697568 - 534 WP_001185622.1 hypothetical protein -
FRO58_RS03370 697613..698542 - 930 WP_000094300.1 hypothetical protein -
FRO58_RS03375 698650..698862 - 213 WP_000121166.1 hypothetical protein -
FRO58_RS03380 698864..699262 - 399 WP_001132270.1 hypothetical protein -
FRO58_RS03385 699264..699632 - 369 WP_000539752.1 hypothetical protein -
FRO58_RS03390 699604..700008 - 405 WP_000248324.1 hypothetical protein -
FRO58_RS03395 700017..700430 - 414 WP_001197735.1 hypothetical protein -
FRO58_RS03400 700387..700776 - 390 WP_000008492.1 hypothetical protein -
FRO58_RS03405 700781..701446 - 666 WP_000767881.1 stress-responsive nuclear envelope protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 672481..727096 54615


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6695.84 Da        Isoelectric Point: 10.5523

>T172674 WP_000838146.1 NZ_CP061517:c696703-696521 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPNGTVKSILKQAGLN

Download         Length: 183 bp

>T172674 NZ_CP079860:1225110-1225424 [Vibrio neptunius]
ATGGCTGAAATAATCTGGACTGAGCCAGCGCTATCTGACCTCAATGATATCGCTGAATACATCGCACTTGAAAATATCGT
AGCTGCAAAAGAATTGGTTCAAGCGATCTTTTCTAAAGTCGAGCGCTTAGAGGCTTTCCCTGAATCGGGTCGCATTCCGC
CTAAACTAGAACATCTAAGTTATCGTGAAGTTGTAGTTAATCCGTGCCGTATTTTCTATAAACAAGACGGCGACAAAGTA
TTTATTCTGTTTGTTATGCGTTCTGAGAGAGACTTGCGTAAGTTCCTATTGAGCAAGCTGGGAATGAGCGGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14769.78 Da        Isoelectric Point: 4.5000

>AT172674 WP_000966689.1 NZ_CP061517:c696456-696052 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVSVPDIPGCFSAGDTLYEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDQEDYRGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDDNVGKDKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT172674 NZ_CP079860:1224865-1225122 [Vibrio neptunius]
ATGAAAGTAGAACTCGTTACATCACTCAAGCGCCAAGCAACAAAAATCCTTGCCGATCTCCACGAAACTAAAGAACCAGT
GTTAATTACCGAACATGGTAAGCCATCGGCATATCTGGTTGATGTTGATGATTACGAGTTTATGCAAAATCGTTTGGCGA
TTCTGGAGGGGATTGCACGAGGTGAACGTGCATTAGCTGACGGTAAAGTGGTGAGCCACGATGAAGCCAAGGACAAAATG
TCGAAATGGCTGAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S3TWT7

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1AAF8

References