Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3244503..3245129 Replicon chromosome
Accession NZ_CP061513
Organism Morganella morganii strain GDMM86

Toxin (Protein)


Gene name Hha Uniprot ID A0A0A2RCL2
Locus tag IDH72_RS15770 Protein ID WP_024474604.1
Coordinates 3244926..3245129 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A0D8L953
Locus tag IDH72_RS15765 Protein ID WP_025151710.1
Coordinates 3244503..3244862 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDH72_RS15755 3239554..3240750 + 1197 WP_143971663.1 efflux RND transporter periplasmic adaptor subunit -
IDH72_RS15760 3240765..3243941 + 3177 WP_143971664.1 efflux RND transporter permease subunit -
IDH72_RS15765 3244503..3244862 + 360 WP_025151710.1 Hha toxicity modulator TomB Antitoxin
IDH72_RS15770 3244926..3245129 + 204 WP_024474604.1 hemolysin expression modulator Hha Toxin
IDH72_RS15780 3246001..3246864 + 864 WP_143971665.1 acyl-CoA thioesterase II -
IDH72_RS15785 3246925..3248214 - 1290 WP_143971666.1 ammonium transporter AmtB -
IDH72_RS15790 3248234..3248572 - 339 WP_143971667.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-113)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8073.39 Da        Isoelectric Point: 6.9770

>T172668 WP_024474604.1 NZ_CP061513:3244926-3245129 [Morganella morganii]
MTKLDYLMRLRKCTSIETLERVIEKNKYELTDDELEVFYSAADHRLAELTMNKLYDKIPASVWKFVR

Download         Length: 204 bp

>T172668 NZ_CP079859:1632925-1633335 [Vibrio neptunius]
TTGAGTAAAAAAATCAACTATATGCTCGATACGTGTATTTGTTCGTTCATTATGCGAGAGCAACCAATTGCGGTGCTTAA
AAAGCTTCAAACAGTGGTTGGTGAGCAGCATCGAATCGTTATCTCAGCCATTACCTATCAAGAAATGCAGTACGGGTTAT
TGGGGAGAAAAGATGCTGTGCTTGTTGAAGAATTTTTAAAGCGAGTGGATGAGATTTTACCTTGGGATAAAGCAGCTGTT
GATGCAACTACTGAAGTTAAACGCGATCTAATGTCCAAAGGTACACCCATTGGCAACAACGACACTGCTATTGCAGGTCA
CGCCATGTCGACTGGCTGTGTGCTTGTCACGAATAATATAAGAGAGTTTCAGCGTGTCGAAGGACTAGAGCTTGAAGATT
GGGTTCGCTAG

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13856.57 Da        Isoelectric Point: 4.2870

>AT172668 WP_025151710.1 NZ_CP061513:3244503-3244862 [Morganella morganii]
MDEYSPRNYDIAVLKYLCDELCREGTQTLIRSNNYWVNDLASDSNLKLNELLGYIADVTWSFKIKHTQNKDLISFVDEYI
DETYALFGQMEVSFNDVEEWKKMASLVSSMLTSEGHLVH

Download         Length: 360 bp

>AT172668 NZ_CP079859:1632699-1632932 [Vibrio neptunius]
ATGAGAACAGTATCTATTTTTAAAAATGGCAAGAATCAAGCGGTGCGCTTGCCAAAAGATTTTGAGTTTGACGGCGTCAA
TGAGCTTGAAATCCACAAAGAGGGTGATGTCATCACCTTGCGCCCAGTTCGTCCAGATTGGCTTTCATTTGGTGAGCAAG
AAAAGGCTGATAGTGATTTCATGGCAAACCGTGAAGATGTGATGACGGACGAAGGACGATTCAATTTTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2RCL2

Antitoxin

Source ID Structure
AlphaFold DB A0A0D8L953

References