Detailed information of TA system TA172667

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 2950855..2951698
• Replicon: chromosome
• Accession: NZ_CP061513
• Organism: Morganella morganii strain GDMM86

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: IDH72_RS14550
• Protein ID: WP_143971505.1
• Coordinates: 2950855..2951262 (-)
• Length: 136 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: M7CSJ2
• Locus tag: IDH72_RS14555
• Protein ID: WP_004240904.1
• Coordinates: 2951411..2951698 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IDH72_RS14530	2946822..2948555	-	1734	WP_087826207.1	single-stranded-DNA-specific exonuclease RecJ	-
IDH72_RS14535	2948578..2949270	-	693	WP_143971503.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
IDH72_RS14540	2949283..2950197	-	915	WP_143971504.1	site-specific tyrosine recombinase XerD	-
IDH72_RS14545	2950331..2950849	+	519	WP_004238332.1	flavodoxin FldB	-
IDH72_RS14550	2950855..2951262	-	408	WP_143971505.1	protein YgfX	Toxin
IDH72_RS14555	2951411..2951698	-	288	WP_004240904.1	FAD assembly factor SdhE	Antitoxin
IDH72_RS14560	2951975..2952958	+	984	WP_143971506.1	tRNA-modifying protein YgfZ	-
IDH72_RS14565	2953037..2953642	+	606	WP_143971507.1	HD domain-containing protein	-
IDH72_RS14570	2953696..2956572	-	2877	WP_143971508.1	aminomethyl-transferring glycine dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (8-80)

Sequences

Toxin

Protein

• Length: 136 a.a.
• Molecular weight: 15637.38 Da
• Isoelectric Point: 11.5427

>T172667 WP_143971505.1 NZ_CP061513:c2951262-2950855 [Morganella morganii]
VVLWKSVLRVSFKTQVFSTLIYGVLALSVLFAPWPGRTSFIWLPLTLLLIAGWGRTQYKISKRAGPASLQNQNRILWRKS
EWEITRPPYITRLGIRLHLRSLTSGRQKYLWIASDSVPQEAWSSLNQLLLQYPDI

Nucleotide

• Length: 408 bp

>T172667 NZ_CP079855:c1979601-1979332 [Agrobacterium fabrum]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGACTATGAGTTCTGGCAAAGAACCGATGCTCGCATGGTCGAGAAAAT
AAACGATCTTATCCGAAATGCCAAACGCACGCCCTTTGCAGGGCTTGGGAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTACCGCCGAGCATCGGTTTGTCTACCGTGTATCCGGGTCCGGAAGCGAGCAACGGCTGGAA
GTCATTCAGTGCCGCTTCCATTACCAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 11298.84 Da
• Isoelectric Point: 4.7921

>AT172667 WP_004240904.1 NZ_CP061513:c2951698-2951411 [Morganella morganii]
VLDIENKARIHWACRRGMRELDIAIMPFFQHEYDTLTDAQKQDFVQLLNCPDPDLFNWLMNKGRPDDEALYQIIRLIQER
NQARMAAQNAAYYPD

Nucleotide

• Length: 288 bp

>AT172667 NZ_CP079855:c1979852-1979598 [Agrobacterium fabrum]
ATGGCGAATGTGCGATTTACCGAGTTCAGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAAACCCGCGCGCCATT
GCTCGTCACGCGGCAAGGCAAAGAGGCGGTCGTGGTGCTTGCCGAAGGAGAATATGAGAGCATGCAGGAAACGCTGCATC
TCCTGTCCAACCCGGCAAATGCCTCAAGGCTTCGCGCGTCCATGGGCGAACTTGAGCGCGGTGACACCATCGAGCGGGAT
CCGACCGAAGAATGA

Structures

Antitoxin

• AlphaFold DB: M7CSJ2