Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 3181494..3182130 Replicon chromosome
Accession NZ_CP061474
Organism Geobacillus sp. 46C-IIa

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC803_RS15935 Protein ID WP_003253417.1
Coordinates 3181494..3181844 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID S5ZZQ7
Locus tag IC803_RS15940 Protein ID WP_020958454.1
Coordinates 3181849..3182130 (-) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC803_RS15925 3177897..3178898 - 1002 WP_081210571.1 LacI family DNA-binding transcriptional regulator -
IC803_RS15930 3179032..3181194 - 2163 WP_081210569.1 RNA-binding transcriptional accessory protein -
IC803_RS15935 3181494..3181844 - 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IC803_RS15940 3181849..3182130 - 282 WP_020958454.1 hypothetical protein Antitoxin
IC803_RS15945 3182258..3183412 - 1155 WP_081210567.1 alanine racemase -
IC803_RS15950 3183702..3184715 - 1014 WP_081210565.1 outer membrane lipoprotein carrier protein LolA -
IC803_RS15955 3184795..3185184 - 390 WP_081210563.1 holo-ACP synthase -
IC803_RS15960 3185334..3185951 + 618 WP_081210561.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172660 WP_003253417.1 NZ_CP061474:c3181844-3181494 [Geobacillus sp. 46C-IIa]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172660 NZ_CP079839:2064771-2066099 [Salmonella enterica]
ATGCGTCGAACACAGCAGCGTTTAGCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTCATTACAATATCTTCCAGAATGGGTAGTTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCCGGTA
ATCAGCTTTGGCGCGGTAACGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCCGTGCGTTACCAGTCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGCGCAATACA
GTTACTGGATGTTGATGAAGAGCCCACGGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATAGCCACTA
CATTGCGTAATACTACGGCGGCATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGTTTATCAATTGCCGGTGCG
CAAGAAAAAACGGCTTTATTGTGGCATGAAGAACAATGGTGTTTACCAGAAGGTAATACCCCAACAACGCATATCTTCAA
GCTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTC
TTGAGCACTACGGAATCCCTGTAGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAGGCATTAGTGGTTGAACGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCCCAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGACATATTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCGCAAATTATTTTCTGGTTGTTGGCTGCTACTGATGGCCATGCCAAAAATTTTAGT
ATCGCTATTGAGCCACAAAGTCATTACCACCTTACGCCTCTTTACGATGTTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTCACTGGCAGAGATGCAAACTGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAA
TTCAACGACGGCATTGGATCAATCATGGTGAATTAAACGGATTGGGAAGACGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGCACGCCAGAAGTCATTGAGCGTGTATCTGCGTTGCTTCCAGAGTCGTTTCCACTAGAGCTTGCTGAGTGTAT
TTTTGATGGCATGCGGCAGCAGTGTGGGCGTTTGGCTGAAAGAGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10641.11 Da        Isoelectric Point: 7.2027

>AT172660 WP_020958454.1 NZ_CP061474:c3182130-3181849 [Geobacillus sp. 46C-IIa]
VSESGATTEIIVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172660 NZ_CP079839:2064461-2064766 [Salmonella enterica]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATACGCCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACCTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTTGAAATGGTACTCTCTTCTGGACCACAGATACTTTCCTCGATG
TCATCTTCAACAATGGATGAATCAGAACAACAAAAAGATTCACCTGCCAGAAGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A143ML40

References