Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2179473..2180109 Replicon chromosome
Accession NZ_CP061473
Organism Geobacillus sp. 47C-IIb

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC804_RS11095 Protein ID WP_003253417.1
Coordinates 2179759..2180109 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A0Q1ENP8
Locus tag IC804_RS11090 Protein ID WP_008881474.1
Coordinates 2179473..2179754 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC804_RS11070 2175656..2176273 - 618 WP_008881478.1 rhomboid family intramembrane serine protease -
IC804_RS11075 2176414..2176803 + 390 WP_008881477.1 holo-ACP synthase -
IC804_RS11080 2176883..2177896 + 1014 WP_008881476.1 outer membrane lipoprotein carrier protein LolA -
IC804_RS11085 2178191..2179345 + 1155 WP_081157204.1 alanine racemase -
IC804_RS11090 2179473..2179754 + 282 WP_008881474.1 hypothetical protein Antitoxin
IC804_RS11095 2179759..2180109 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IC804_RS11100 2180770..2182935 + 2166 WP_029761551.1 RNA-binding transcriptional accessory protein -
IC804_RS11105 2182952..2183065 - 114 WP_087959817.1 cortex morphogenetic protein CmpA -
IC804_RS11110 2183156..2183644 + 489 WP_008881471.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172659 WP_003253417.1 NZ_CP061473:2179759-2180109 [Geobacillus sp. 47C-IIb]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172659 NZ_CP079839:1990535-1990819 [Salmonella enterica]
ATGACCTATGAGCTGGAGTTTGATCCACGCGCGCTAAAAGAGTGGCAAAAGCTGGGTGAAACGGTAAAAAAACAGTTCCG
CAAGAAACTTGTCGACGTGTTGTCAAATCCGCGGGTTGAGTCTGCGCGGCTGCGTGAACTGCCAGATTGCTACAAAATCA
AGCTGAAGACCTCAGGCTATCGTTTAGTGTATCAGGTGCAGGACGACGTGGTATTGGTGGTGGTGATTGCTATCGGCAAG
AGAGAGAAATCGGCCGTTTATCGCCAGGCAGACAAACGGCTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10627.09 Da        Isoelectric Point: 7.2027

>AT172659 WP_008881474.1 NZ_CP061473:2179473-2179754 [Geobacillus sp. 47C-IIb]
VSESGATTEIVVRLPQSLLTELDGLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172659 NZ_CP079839:1990303-1990545 [Salmonella enterica]
ATGGCCACACTTAACGTCCGTTTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
CACAGAAGCTGTCCGGCTGTTGTTTCAATATGTGGCGGAAAACGGGCGTATGCCTGTTAAAACCGTTACGATTAGCGACA
GCGAAGACGTATTGCTACAGACAGTCCGGGAACGACTGGCTAACCCACAGAAAGGAATCAGAGTTAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A0Q1ENP8

References