Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2670130..2670766 Replicon chromosome
Accession NZ_CP061472
Organism Geobacillus thermoleovorans strain SURF-48B

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC805_RS13570 Protein ID WP_003253417.1
Coordinates 2670416..2670766 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag IC805_RS13565 Protein ID WP_011229742.1
Coordinates 2670130..2670411 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC805_RS13545 2666387..2667004 - 618 WP_014194682.1 rhomboid family intramembrane serine protease -
IC805_RS13550 2667118..2667507 + 390 WP_011229738.1 holo-ACP synthase -
IC805_RS13555 2667587..2668600 + 1014 WP_014194683.1 outer membrane lipoprotein carrier protein LolA -
IC805_RS13560 2668849..2670003 + 1155 WP_011229741.1 alanine racemase -
IC805_RS13565 2670130..2670411 + 282 WP_011229742.1 hypothetical protein Antitoxin
IC805_RS13570 2670416..2670766 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IC805_RS13575 2671032..2673197 + 2166 WP_021322019.1 RNA-binding transcriptional accessory protein -
IC805_RS13580 2673216..2673329 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
IC805_RS13585 2673419..2673868 + 450 WP_011229744.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172658 WP_003253417.1 NZ_CP061472:2670416-2670766 [Geobacillus thermoleovorans]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172658 NZ_CP079839:c1873053-1872709 [Salmonella enterica]
ATGCAAAACGTTTTATCACTGCCTTCACCGGCAGCGGCCCCGTCACGCCTGTCGCCCATCGAAGCCTGGCGAAAACTGCT
GTCGTATTTACTGCAACGCCACTACGGCCTTGAACTTAACGACACACCATTCTGCGACGATATTGTTATTCAGGAGCATA
TCAACGCCGGTATTACGCTGGCTGATGCTGTTAACTTTCTGGTGGAAAAGTACGAGCTGGTTCGTATCGATCGCAGGGGG
TTTAACTGTCAGGAGCAGTCACCTTATCTTTGGGCGGTAGATATTTTACGGGCAAGGCAGGCAACCGGCCTGTTACGGCA
AAGCCGTCATCCTCCGACACGCTGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT172658 WP_011229742.1 NZ_CP061472:2670130-2670411 [Geobacillus thermoleovorans]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172658 NZ_CP079839:c1873397-1873068 [Salmonella enterica]
ATGTCCCAAAACCAACCCTCTATGCCTGTCTGGGGTCTGCGGAGCGATATCACGCCCTCGTTTGGCGCGCGGTTAGTGCA
GGAAGGCCGTCGCCTGCATTTTCTGGCCGACCGCGCCAGCCTTTGCGGTGATTTCACGCTGGAGCAACTGAAAACACTGG
ACGCCACCTTTTCGCAGTTCTTGAAACAACTGGAATCGGCGCTGAAAAGCGGGGCGCTCGATCCGCGCCAGCCGCACCGC
CACAACATCACCCTCAATGGCCTGACCTGCGAAGCCGACACCAACGGTAGCTACGGCTACGTTTATCTCACTATCTACCC
GACCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References