Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 1157706..1158304 Replicon chromosome
Accession NZ_CP061472
Organism Geobacillus thermoleovorans strain SURF-48B

Toxin (Protein)


Gene name mazF Uniprot ID G8N5V4
Locus tag IC805_RS05855 Protein ID WP_011231143.1
Coordinates 1157975..1158304 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G8N5V3
Locus tag IC805_RS05850 Protein ID WP_011231142.1
Coordinates 1157706..1157975 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC805_RS05815 1153406..1154386 + 981 WP_011231139.1 ABC transporter permease -
IC805_RS05820 1154455..1154922 - 468 WP_021321939.1 hypothetical protein -
IC805_RS05825 1154936..1155700 - 765 WP_011231140.1 hypothetical protein -
IC805_RS05830 1155827..1156882 + 1056 WP_011231141.1 transposase -
IC805_RS05850 1157706..1157975 + 270 WP_011231142.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IC805_RS05855 1157975..1158304 + 330 WP_011231143.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IC805_RS05860 1158757..1159590 + 834 WP_011231146.1 pirin family protein -
IC805_RS05865 1159686..1160435 + 750 WP_011231147.1 oxygen-insensitive NADPH nitroreductase -
IC805_RS05870 1160625..1161368 + 744 WP_011231148.1 NAD-dependent protein deacylase -
IC805_RS05875 1161548..1162726 + 1179 WP_011231149.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(12-87)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12071.86 Da        Isoelectric Point: 7.1331

>T172657 WP_011231143.1 NZ_CP061472:1157975-1158304 [Geobacillus thermoleovorans]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS

Download         Length: 330 bp

>T172657 NZ_CP079839:c1161759-1161607 [Salmonella enterica]
ATGCCGCAGAAAGGTATGTTATACAGTTTAATAGTGATATGTCTCACTATTTTATTATTTACCTGGATAGTTCGTGATTC
ACTGTGTGAATTACATATCCGCCAGGGAAATAATGAGCTGGCGGCATCTTTAGCCTGTGATAGCAAACAGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9992.67 Da        Isoelectric Point: 7.2050

>AT172657 WP_011231142.1 NZ_CP061472:1157706-1157975 [Geobacillus thermoleovorans]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF

Download         Length: 270 bp

>AT172657 NZ_CP079839:1161810-1161865 [Salmonella enterica]
GTTCAAGCATAGAGGTGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9EUB7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9HWH2

References