Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 1157706..1158304 | Replicon | chromosome |
Accession | NZ_CP061472 | ||
Organism | Geobacillus thermoleovorans strain SURF-48B |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G8N5V4 |
Locus tag | IC805_RS05855 | Protein ID | WP_011231143.1 |
Coordinates | 1157975..1158304 (+) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G8N5V3 |
Locus tag | IC805_RS05850 | Protein ID | WP_011231142.1 |
Coordinates | 1157706..1157975 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IC805_RS05815 | 1153406..1154386 | + | 981 | WP_011231139.1 | ABC transporter permease | - |
IC805_RS05820 | 1154455..1154922 | - | 468 | WP_021321939.1 | hypothetical protein | - |
IC805_RS05825 | 1154936..1155700 | - | 765 | WP_011231140.1 | hypothetical protein | - |
IC805_RS05830 | 1155827..1156882 | + | 1056 | WP_011231141.1 | transposase | - |
IC805_RS05850 | 1157706..1157975 | + | 270 | WP_011231142.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
IC805_RS05855 | 1157975..1158304 | + | 330 | WP_011231143.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
IC805_RS05860 | 1158757..1159590 | + | 834 | WP_011231146.1 | pirin family protein | - |
IC805_RS05865 | 1159686..1160435 | + | 750 | WP_011231147.1 | oxygen-insensitive NADPH nitroreductase | - |
IC805_RS05870 | 1160625..1161368 | + | 744 | WP_011231148.1 | NAD-dependent protein deacylase | - |
IC805_RS05875 | 1161548..1162726 | + | 1179 | WP_011231149.1 | acyl-CoA dehydrogenase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12071.86 Da Isoelectric Point: 7.1331
>T172657 WP_011231143.1 NZ_CP061472:1157975-1158304 [Geobacillus thermoleovorans]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS
Download Length: 330 bp
>T172657 NZ_CP079839:c1161759-1161607 [Salmonella enterica]
ATGCCGCAGAAAGGTATGTTATACAGTTTAATAGTGATATGTCTCACTATTTTATTATTTACCTGGATAGTTCGTGATTC
ACTGTGTGAATTACATATCCGCCAGGGAAATAATGAGCTGGCGGCATCTTTAGCCTGTGATAGCAAACAGTAA
ATGCCGCAGAAAGGTATGTTATACAGTTTAATAGTGATATGTCTCACTATTTTATTATTTACCTGGATAGTTCGTGATTC
ACTGTGTGAATTACATATCCGCCAGGGAAATAATGAGCTGGCGGCATCTTTAGCCTGTGATAGCAAACAGTAA
Antitoxin
Download Length: 90 a.a. Molecular weight: 9992.67 Da Isoelectric Point: 7.2050
>AT172657 WP_011231142.1 NZ_CP061472:1157706-1157975 [Geobacillus thermoleovorans]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF
Download Length: 270 bp
>AT172657 NZ_CP079839:1161810-1161865 [Salmonella enterica]
GTTCAAGCATAGAGGTGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG
GTTCAAGCATAGAGGTGGCCTCACTTTGATTTATAGTCAGGTGGGGCTTTTCTCTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9EUB7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9HWH2 |