172656

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 462267..463083 Replicon chromosome
Accession NZ_CP061472
Organism Geobacillus thermoleovorans strain SURF-48B

Toxin (Protein)


Gene name hepT Uniprot ID G8MYR9
Locus tag IC805_RS02275 Protein ID WP_014195290.1
Coordinates 462267..462686 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID G8MYS0
Locus tag IC805_RS02280 Protein ID WP_014195291.1
Coordinates 462676..463083 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC805_RS02250 459042..459557 + 516 WP_014195285.1 GNAT family N-acetyltransferase -
IC805_RS02255 459629..460900 + 1272 WP_122983902.1 DUF3533 domain-containing protein -
IC805_RS02260 460925..461137 + 213 WP_020278664.1 ATP-binding cassette domain-containing protein -
IC805_RS02265 461104..461574 + 471 Protein_445 ABC transporter permease -
IC805_RS02270 461586..462239 + 654 WP_014195289.1 TetR/AcrR family transcriptional regulator -
IC805_RS02275 462267..462686 - 420 WP_014195290.1 DUF86 domain-containing protein Toxin
IC805_RS02280 462676..463083 - 408 WP_014195291.1 nucleotidyltransferase domain-containing protein Antitoxin
IC805_RS02285 463364..465496 - 2133 WP_014195292.1 ATP-dependent Clp protease ATP-binding subunit -
IC805_RS02290 465764..466510 + 747 WP_025039183.1 FixH family protein -
IC805_RS02295 466618..467658 + 1041 WP_014195294.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15907.43 Da        Isoelectric Point: 8.2859

>T172656 WP_014195290.1 NZ_CP061472:c462686-462267 [Geobacillus thermoleovorans]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIVLNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSISKKMKAMVGFRNIAVHDYQQLNLGILQAIVEHHLDDFKQFTKAILDYAKKNS

Download         Length: 420 bp

>T172656 NZ_CP079839:c392212-391799 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGTTGCTATTGTCGCTGGTCGTGTTCGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGTCAGGGGGAGATCAAGCTACTCATGGACGGACGTTTACGCTGGCAGGGGCAA
GACTGGACGCTCTTGCATCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCTGAGTCTGGACGCCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATAGTGTTACAGCAACCGATAT
CGCGCCAACACTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15273.46 Da        Isoelectric Point: 4.8382

>AT172656 WP_014195291.1 NZ_CP061472:c463083-462676 [Geobacillus thermoleovorans]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGTLRPDSDVDIAFVSDGEPHDPYELFRLAGELADKLGRDVDLVDLRQAST
VFQAQVVSTGKAIDCRDERKRAEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 408 bp

>AT172656 NZ_CP079839:c392459-392193 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGCTGATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G8MYR9

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9EPL2

References