Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 3129164..3129980 Replicon chromosome
Accession NZ_CP061471
Organism Geobacillus zalihae strain SURF-114

Toxin (Protein)


Gene name hepT Uniprot ID -
Locus tag IC806_RS15765 Protein ID WP_190305139.1
Coordinates 3129164..3129583 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID -
Locus tag IC806_RS15770 Protein ID WP_190305140.1
Coordinates 3129573..3129980 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC806_RS15740 3125938..3126456 + 519 WP_033005521.1 GNAT family N-acetyltransferase -
IC806_RS15745 3126592..3127797 + 1206 WP_050572305.1 DUF3533 domain-containing protein -
IC806_RS15750 3127822..3128034 + 213 WP_020278664.1 ATP-binding cassette domain-containing protein -
IC806_RS15755 3128001..3128471 + 471 Protein_3030 ABC transporter permease -
IC806_RS15760 3128483..3129136 + 654 WP_033024961.1 TetR/AcrR family transcriptional regulator -
IC806_RS15765 3129164..3129583 - 420 WP_190305139.1 DUF86 domain-containing protein Toxin
IC806_RS15770 3129573..3129980 - 408 WP_190305140.1 nucleotidyltransferase domain-containing protein Antitoxin
IC806_RS15775 3130260..3132392 - 2133 WP_190305141.1 ATP-dependent Clp protease ATP-binding subunit -
IC806_RS15780 3132660..3133406 + 747 WP_081132891.1 FixH family protein -
IC806_RS15785 3133514..3134554 + 1041 WP_013145950.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(14-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15855.40 Da        Isoelectric Point: 8.7031

>T172655 WP_190305139.1 NZ_CP061471:c3129583-3129164 [Geobacillus zalihae]
MKSDVILNKISVIERCLKRIREEYNGDPKNLQNYTKQDSIILNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSVSKKMKAMVGFRNIAVHNYQQLNLGILQAIIDHHLDDFKHFAKAILDYAKKNG

Download         Length: 420 bp

>T172655 NZ_CP079838:4450097-4450441 [Salmonella enterica subsp. salamae]
ATGCAAAACGTTTTATCACTGCCTTCACCGGCAGCGGCCCCGTCACGCCTGTCGCCCATCGAAGCCTGGCGAAAACTGCT
GTCGTATTTACTGCAACGCCACTACGGCCTTGAACTTAACGACACACCATTCTGCGACGATATTGTTATTCAGGAGCATA
TCAACGCCGGTATTACGCTGGCTGATGCTGTTAACTTTCTGGTGGAAAAGTACGAGCTGGTTCGTATCGATCGCAGGGGG
TTTAACTGTCAGGAGCAGTCACCTTATCTTTGGGCGGTAGATATTTTACGGGCAAGGCAGGCAACCGGCCTGTTACGGCA
AAGCCGTCATCCTCCAACACGCTGA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15280.55 Da        Isoelectric Point: 4.9959

>AT172655 WP_190305140.1 NZ_CP061471:c3129980-3129573 [Geobacillus zalihae]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGAMRSDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQAST
VFQAQVVSSGKVIDCCDERKRMEFEMKTLKMYVKLNEERAPVLKQITESGSIYEK

Download         Length: 408 bp

>AT172655 NZ_CP079838:4449753-4450082 [Salmonella enterica subsp. salamae]
ATGTCCCAAAACCAACCCTCTATGCCTGTCTGGGGTCTGCGGAGCGATATCACGCCCTCGTTTGGCGCGCGGTTAGTGCA
GGAAGGCCGTCGCCTGCATTTTCTGGCCGACCGCGCCAGCCTTTGCGGTGATTTCACGCTGGAGCAACTGAAAACACTGG
ACGCCACCTTTTCGCAGTTCTTGAAACAACTGGAATCGGCGCTGAAAAGCGGGGCGCTCGATCCGCGCCAGCCGCACCGC
CACAACATCACCCTCAATGGCCTGACCTGCGAAGCCGACACCAACGGTAGCTACGGCTACGTTTATCTCACTATCTACCC
GACCGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References