Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2420243..2420879 Replicon chromosome
Accession NZ_CP061471
Organism Geobacillus zalihae strain SURF-114

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC806_RS12205 Protein ID WP_003253417.1
Coordinates 2420529..2420879 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag IC806_RS12200 Protein ID WP_011229742.1
Coordinates 2420243..2420524 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC806_RS12180 2416501..2417118 - 618 WP_011229737.1 rhomboid family intramembrane serine protease -
IC806_RS12185 2417232..2417594 + 363 WP_015373790.1 holo-ACP synthase -
IC806_RS12190 2417700..2418713 + 1014 WP_013144042.1 outer membrane lipoprotein carrier protein LolA -
IC806_RS12195 2418962..2420116 + 1155 WP_081133139.1 alanine racemase -
IC806_RS12200 2420243..2420524 + 282 WP_011229742.1 hypothetical protein Antitoxin
IC806_RS12205 2420529..2420879 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IC806_RS12210 2421211..2423376 + 2166 WP_190305035.1 RNA-binding transcriptional accessory protein -
IC806_RS12215 2423395..2423508 - 114 WP_089135018.1 cortex morphogenetic protein CmpA -
IC806_RS12220 2423598..2423945 + 348 Protein_2365 SprT family protein -
IC806_RS12225 2424019..2425064 + 1046 Protein_2366 IS630-like element ISBs2 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172654 WP_003253417.1 NZ_CP061471:2420529-2420879 [Geobacillus zalihae]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172654 NZ_CP079838:c4332616-4332332 [Salmonella enterica subsp. salamae]
ATGACCTATGAGCTGGAGTTTGATCCACGCGCGCTAAAAGAGTGGCAAAAGCTGGGTGAAACGGTAAAAAAACAGTTCCG
CAAGAAACTTGTCGACGTGTTGTCAAATCCGCGGGTTGAGTCTGCGCGGCTGCGTGAACTGCCAGATTGCTACAAAATCA
AGCTGAAGACCTCAGGCTATCGTTTAGTGTATCAGGTGCAGGACGACGTGGTATTGGTGGTGGTGATTGCTATCGGCAAG
AGAGAGAAATCGGCCGTTTATCGCCAGGCAGACAAACGGCTTTAG

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT172654 WP_011229742.1 NZ_CP061471:2420243-2420524 [Geobacillus zalihae]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172654 NZ_CP079838:c4332848-4332606 [Salmonella enterica subsp. salamae]
ATGGCCACACTTAACGTCCGTTTGGATGACAAACTCAAAAACGAGGCTTATGCCGTGCTGGAAAAACTCAATATTACCCC
CACAGAAGCTGTCCGGCTGTTGTTTCAATATGTGGCGGAAAACGGGCGTATGCCTGTTAAAACCGTTACGATTAGCGACA
GCGAAGACGTATTGCTACAGACAGTCCGGGAACGACTGGCTAACCCACAGAAAGGAATCAGAGTTAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References