Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 291173..291771 Replicon chromosome
Accession NZ_CP061471
Organism Geobacillus zalihae strain SURF-114

Toxin (Protein)


Gene name mazF Uniprot ID G8N5V4
Locus tag IC806_RS01460 Protein ID WP_011231143.1
Coordinates 291442..291771 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G8N5V3
Locus tag IC806_RS01455 Protein ID WP_011231142.1
Coordinates 291173..291442 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC806_RS01415 286922..287221 + 300 WP_190305409.1 transporter suffix domain-containing protein -
IC806_RS01420 287231..288028 + 798 WP_190305231.1 SGNH/GDSL hydrolase family protein -
IC806_RS01425 288025..288939 + 915 WP_055358979.1 ABC transporter ATP-binding protein -
IC806_RS01430 288932..289912 + 981 WP_011231139.1 ABC transporter permease -
IC806_RS01435 289981..290490 - 510 WP_190305232.1 hypothetical protein -
IC806_RS01455 291173..291442 + 270 WP_011231142.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IC806_RS01460 291442..291771 + 330 WP_011231143.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IC806_RS01465 291803..292042 - 240 WP_020753918.1 hypothetical protein -
IC806_RS01470 292228..293061 + 834 WP_015374778.1 pirin family protein -
IC806_RS01475 293157..293906 + 750 WP_081133353.1 oxygen-insensitive NADPH nitroreductase -
IC806_RS01480 293980..294723 + 744 WP_015374780.1 NAD-dependent protein deacylase -
IC806_RS01485 294904..296082 + 1179 WP_081133229.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(12-87)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12071.86 Da        Isoelectric Point: 7.1331

>T172653 WP_011231143.1 NZ_CP061471:291442-291771 [Geobacillus zalihae]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS

Download         Length: 330 bp

>T172653 NZ_CP079838:c4258372-4257044 [Salmonella enterica subsp. salamae]
ATGCGTCGAACACAGCAGCGTTTAGCAATATGGATGAATGGAATCCGGGTCGGATTCTGGGAGAAGGCCAGAGGCGAGGA
TTCATTACAATATCTTCCAGAATGGGTAGTTGATGAACAGGGAAGACCTTTATCGCTTTCTTTGCCTTTCACTCCCGGTA
ATCAGCTTTGGCGCGGTAACGTTGTTCGTGACTATTTTGATAATTTATTGCCTGACAGCGAAGGTATACGCAGGCGTTTA
GCCGTGCGTTACCAGTCTGAAAGCCTTGAGCCTTTTGATCTATTGGCTGAGCTGGGAAGAGACTGCGTTGGCGCAATACA
GTTACTGGATGTTGATGAAGAGCCCACGGATTTATTTTCCGTAAATTATCGCCCACTTTCTGAAGCTGATATAGCCACTA
CATTGCGTAATACTACGGCGGCATCGTTGCCTGGTCGGCAGGACGAAACTGACGATTTGCGTTTATCAATTGCCGGTGCG
CAAGAAAAAACGGCTTTATTGTGGCATGAAGAACAATGGTGTTTACCAGAAGGTAATACCCCAACAACGCATATCTTCAA
GCTACCGCTTGGGTTGGTTGGGAACATGCAAGCGGATATGAGTACATCGGTTGAAAATGAATGGCTGTGTTCTTTGCTTC
TTGAGCACTACGGAATCCCTGTAGCAAAAACACAGATTGCGCAGTTTGAAGATCAGAAGGCATTAGTGGTTGAACGTTTC
GACAGAAGATGGTCAGGCGATCGGCAATGGATCATTCGTTTGCCCCAAGAGGATATGTGTCAGGCTTTAGGTGTTTCTCC
GTTACGAAAATACCAGTCTGATGGTGGGCCGGGTATTTCCGATATTATGGACATATTGAGTCATTCAGATCAGGCTGAGC
AGGACAAAGAGCAGTTCTTCAGGGCGCAAATTATTTTCTGGTTGTTGGCTGCTACTGATGGCCATGCCAAAAATTTTAGT
ATCGCTATTGAGCCACAAAGTCATTACCACCTTACGCCTCTTTACGATGTTTTATCAGCATGGCCGGTAATTGGTCATGG
TAATAATCAGATTCACTGGCAGAGATGCAAACTGGCAATGGCTGTTCGCGGTAGCAGTAATTATTACCACATTTATAGAA
TTCAACGACGGCATTGGATCAATCATGGTGAATTAAACGGATTGGGAAGACGACAAGTTGAGTCCATGATGGATGACATT
ATATCCAGCACGCCAGAAGTCATTGAGCGTGTATCTGCGTTGCTTCCAGAGTCGTTTCCACTAGAGCTTGCTGAGTGTAT
TTTTGATGGCATGCGGCAGCAGTGTGGGCGTTTGGCTGAAAGAGGGTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9992.67 Da        Isoelectric Point: 7.2050

>AT172653 WP_011231142.1 NZ_CP061471:291173-291442 [Geobacillus zalihae]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF

Download         Length: 270 bp

>AT172653 NZ_CP079838:c4258682-4258377 [Salmonella enterica subsp. salamae]
ATGAATACTGTTTATCCGTTGAAAACTTTGAATCAAATACGCCCATTGCTGATTGGCTTTCGCAAGGCTAATGGACTGAC
ACAAAAGGAAGTTTCTGAAAGGTTAGGAGTAACTCAGCAAACCTATGCCCGACTGGAAGCGAATCCAGCCAGTGCCAGTA
TGGAGCGACTATTCAGGGTATTTACCGTGCTGGGTGTTGAAATGGTACTCTCTTCTGGACCACAGATACTTTCCTCGATG
TCATCTTCAACAATGGATGAATCAGAACAACAAAAAGATTCACCTGCCAGAAGGGAAAAATGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9EUB7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9HWH2

References