Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2928218..2928854 Replicon chromosome
Accession NZ_CP061470
Organism Geobacillus zalihae strain SURF-189

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC807_RS14735 Protein ID WP_003253417.1
Coordinates 2928504..2928854 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag IC807_RS14730 Protein ID WP_011229742.1
Coordinates 2928218..2928499 (+) Length 94 a.a.

Genomic Context

IC807_RS14715IC807_RS14720IC807_RS14725IC807_RS14730IC807_RS14735IC807_RS14740IC807_RS14750IC807_RS14710IC807_RS14745
Location: 2925206..2925595 (390 bp)
Type: Others
Protein ID: WP_011229738.1
Location: 2925675..2926688 (1014 bp)
Type: Others
Protein ID: WP_033004654.1
Location: 2926937..2928091 (1155 bp)
Type: Others
Protein ID: WP_020278946.1
Location: 2928218..2928499 (282 bp)
Type: Antitoxin
Protein ID: WP_011229742.1
Location: 2928504..2928854 (351 bp)
Type: Toxin
Protein ID: WP_003253417.1
Location: 2929186..2931351 (2166 bp)
Type: Others
Protein ID: WP_020753664.1
Location: 2931573..2932022 (450 bp)
Type: Others
Protein ID: WP_013144047.1
Location: 2924475..2925092 (618 bp)
Type: Others
Protein ID: WP_020753661.1
Location: 2931370..2931483 (114 bp)
Type: Others
Protein ID: WP_013144046.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IC807_RS147102924475..2925092-618WP_020753661.1rhomboid family intramembrane serine protease-
IC807_RS147152925206..2925595+390WP_011229738.1holo-ACP synthase-
IC807_RS147202925675..2926688+1014WP_033004654.1outer membrane lipoprotein carrier protein LolA-
IC807_RS147252926937..2928091+1155WP_020278946.1alanine racemase-
IC807_RS147302928218..2928499+282WP_011229742.1hypothetical proteinAntitoxin
IC807_RS147352928504..2928854+351WP_003253417.1type II toxin-antitoxin system endoribonuclease NdoAToxin
IC807_RS147402929186..2931351+2166WP_020753664.1RNA-binding transcriptional accessory protein-
IC807_RS147452931370..2931483-114WP_013144046.1cortex morphogenetic protein CmpA-
IC807_RS147502931573..2932022+450WP_013144047.1SprT family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172652 WP_003253417.1 NZ_CP061470:2928504-2928854 [Geobacillus zalihae]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172652 NZ_CP079838:3639895-3640113 [Salmonella enterica subsp. salamae]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATCCCTTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT172652 WP_011229742.1 NZ_CP061470:2928218-2928499 [Geobacillus zalihae]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172652 NZ_CP079838:3639493-3639867 [Salmonella enterica subsp. salamae]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBA0A7U9ERQ4

Antitoxin

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Source
ID
Structure
AlphaFold DBA0A7U9ETW5

References