Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazF-pemI/MazF(toxin)
Location 2928218..2928854 Replicon chromosome
Accession NZ_CP061470
Organism Geobacillus zalihae strain SURF-189

Toxin (Protein)


Gene name mazF Uniprot ID L7ZVP1
Locus tag IC807_RS14735 Protein ID WP_003253417.1
Coordinates 2928504..2928854 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID G8N2B5
Locus tag IC807_RS14730 Protein ID WP_011229742.1
Coordinates 2928218..2928499 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC807_RS14710 2924475..2925092 - 618 WP_020753661.1 rhomboid family intramembrane serine protease -
IC807_RS14715 2925206..2925595 + 390 WP_011229738.1 holo-ACP synthase -
IC807_RS14720 2925675..2926688 + 1014 WP_033004654.1 outer membrane lipoprotein carrier protein LolA -
IC807_RS14725 2926937..2928091 + 1155 WP_020278946.1 alanine racemase -
IC807_RS14730 2928218..2928499 + 282 WP_011229742.1 hypothetical protein Antitoxin
IC807_RS14735 2928504..2928854 + 351 WP_003253417.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
IC807_RS14740 2929186..2931351 + 2166 WP_020753664.1 RNA-binding transcriptional accessory protein -
IC807_RS14745 2931370..2931483 - 114 WP_013144046.1 cortex morphogenetic protein CmpA -
IC807_RS14750 2931573..2932022 + 450 WP_013144047.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12992.00 Da        Isoelectric Point: 4.8781

>T172652 WP_003253417.1 NZ_CP061470:2928504-2928854 [Geobacillus zalihae]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLGLIDF

Download         Length: 351 bp

>T172652 NZ_CP079838:3639895-3640113 [Salmonella enterica subsp. salamae]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATCCCTTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10639.14 Da        Isoelectric Point: 7.2027

>AT172652 WP_011229742.1 NZ_CP061470:2928218-2928499 [Geobacillus zalihae]
VSESGATAEIVVRLPQSLLTELDVLVKQENGNRNELIYQATKMYIRERKKRQIREAMRRGYMEMAKINLSIASEAFHAEY
EADHTVERLVSGG

Download         Length: 282 bp

>AT172652 NZ_CP079838:3639493-3639867 [Salmonella enterica subsp. salamae]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9ERQ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9ETW5

References