Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mazEF/PRK09907-MazE |
Location | 854531..855129 | Replicon | chromosome |
Accession | NZ_CP061470 | ||
Organism | Geobacillus zalihae strain SURF-189 |
Toxin (Protein)
Gene name | mazF | Uniprot ID | G8N5V4 |
Locus tag | IC807_RS04315 | Protein ID | WP_011231143.1 |
Coordinates | 854800..855129 (+) | Length | 110 a.a. |
Antitoxin (Protein)
Gene name | mazE | Uniprot ID | G8N5V3 |
Locus tag | IC807_RS04310 | Protein ID | WP_011231142.1 |
Coordinates | 854531..854800 (+) | Length | 90 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IC807_RS04270 | 850279..850578 | + | 300 | WP_014195759.1 | transporter suffix domain-containing protein | - |
IC807_RS04275 | 850588..851385 | + | 798 | WP_020753914.1 | SGNH/GDSL hydrolase family protein | - |
IC807_RS04280 | 851382..852296 | + | 915 | WP_020753915.1 | ABC transporter ATP-binding protein | - |
IC807_RS04285 | 852289..853269 | + | 981 | WP_011231139.1 | ABC transporter permease | - |
IC807_RS04290 | 853338..853847 | - | 510 | WP_020753916.1 | hypothetical protein | - |
IC807_RS04310 | 854531..854800 | + | 270 | WP_011231142.1 | AbrB/MazE/SpoVT family DNA-binding domain-containing protein | Antitoxin |
IC807_RS04315 | 854800..855129 | + | 330 | WP_011231143.1 | type II toxin-antitoxin system PemK/MazF family toxin | Toxin |
IC807_RS04320 | 855585..856418 | + | 834 | WP_020753920.1 | pirin family protein | - |
IC807_RS04325 | 856514..857263 | + | 750 | WP_015374779.1 | oxygen-insensitive NADPH nitroreductase | - |
IC807_RS04330 | 857337..858080 | + | 744 | WP_015374780.1 | NAD-dependent protein deacylase | - |
IC807_RS04335 | 858261..859439 | + | 1179 | WP_013145374.1 | acyl-CoA dehydrogenase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 110 a.a. Molecular weight: 12071.86 Da Isoelectric Point: 7.1331
>T172651 WP_011231143.1 NZ_CP061470:854800-855129 [Geobacillus zalihae]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS
Download Length: 330 bp
>T172651 NZ_CP079838:2217678-2217781 [Salmonella enterica subsp. salamae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 90 a.a. Molecular weight: 9992.67 Da Isoelectric Point: 7.2050
>AT172651 WP_011231142.1 NZ_CP061470:854531-854800 [Geobacillus zalihae]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF
Download Length: 270 bp
>AT172651 NZ_CP079838:c2217783-2217640 [Salmonella enterica subsp. salamae]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9EUB7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9HWH2 |