Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 854531..855129 Replicon chromosome
Accession NZ_CP061470
Organism Geobacillus zalihae strain SURF-189

Toxin (Protein)


Gene name mazF Uniprot ID G8N5V4
Locus tag IC807_RS04315 Protein ID WP_011231143.1
Coordinates 854800..855129 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID G8N5V3
Locus tag IC807_RS04310 Protein ID WP_011231142.1
Coordinates 854531..854800 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC807_RS04270 850279..850578 + 300 WP_014195759.1 transporter suffix domain-containing protein -
IC807_RS04275 850588..851385 + 798 WP_020753914.1 SGNH/GDSL hydrolase family protein -
IC807_RS04280 851382..852296 + 915 WP_020753915.1 ABC transporter ATP-binding protein -
IC807_RS04285 852289..853269 + 981 WP_011231139.1 ABC transporter permease -
IC807_RS04290 853338..853847 - 510 WP_020753916.1 hypothetical protein -
IC807_RS04310 854531..854800 + 270 WP_011231142.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IC807_RS04315 854800..855129 + 330 WP_011231143.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
IC807_RS04320 855585..856418 + 834 WP_020753920.1 pirin family protein -
IC807_RS04325 856514..857263 + 750 WP_015374779.1 oxygen-insensitive NADPH nitroreductase -
IC807_RS04330 857337..858080 + 744 WP_015374780.1 NAD-dependent protein deacylase -
IC807_RS04335 858261..859439 + 1179 WP_013145374.1 acyl-CoA dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(6-107)

Antitoxin

Antitoxin PemI-like

(12-87)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12071.86 Da        Isoelectric Point: 7.1331

>T172651 WP_011231143.1 NZ_CP061470:854800-855129 [Geobacillus zalihae]
MQAPDRGDLVYVNFNPQAGHEQAGKRPGIVLSPKRFNQLTGFAVLCPITRQQKGYPFEVELPSGLAVEGVILTDQVKSLD
WRARQLQIVGRAPNEVVSDCLDLIHTFLS

Download         Length: 330 bp

>T172651 NZ_CP079838:2217678-2217781 [Salmonella enterica subsp. salamae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9992.67 Da        Isoelectric Point: 7.2050

>AT172651 WP_011231142.1 NZ_CP061470:854531-854800 [Geobacillus zalihae]
MELNKQKGVSIMTITVQKWGNSLAVRIPSVIAERLALHQGSEVEMIVENQAIKLIPKKKKPTLEELLAKITPENRHAEID
FGTEGNELF

Download         Length: 270 bp

>AT172651 NZ_CP079838:c2217783-2217640 [Salmonella enterica subsp. salamae]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9EUB7

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9HWH2

References