172650

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 112873..113689 Replicon chromosome
Accession NZ_CP061470
Organism Geobacillus zalihae strain SURF-189

Toxin (Protein)


Gene name hepT Uniprot ID A0A063YVL8
Locus tag IC807_RS00625 Protein ID WP_033005519.1
Coordinates 112873..113292 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID S7SX09
Locus tag IC807_RS00630 Protein ID WP_020754944.1
Coordinates 113282..113689 (-) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC807_RS00600 109647..110165 + 519 WP_033005521.1 GNAT family N-acetyltransferase -
IC807_RS00605 110301..111506 + 1206 WP_050572305.1 DUF3533 domain-containing protein -
IC807_RS00610 111531..111743 + 213 WP_020278664.1 ATP-binding cassette domain-containing protein -
IC807_RS00615 111710..112180 + 471 Protein_121 ABC transporter permease -
IC807_RS00620 112192..112845 + 654 WP_033024961.1 TetR/AcrR family transcriptional regulator -
IC807_RS00625 112873..113292 - 420 WP_033005519.1 DUF86 domain-containing protein Toxin
IC807_RS00630 113282..113689 - 408 WP_020754944.1 nucleotidyltransferase domain-containing protein Antitoxin
IC807_RS00635 113876..114475 - 600 WP_033005529.1 hypothetical protein -
IC807_RS00640 114497..115009 - 513 WP_020754942.1 hypothetical protein -
IC807_RS00645 115229..117364 - 2136 WP_033005518.1 ATP-dependent Clp protease ATP-binding subunit -
IC807_RS00650 117632..118378 + 747 WP_033005516.1 FixH family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(15-131)

Antitoxin

Polymerase beta, nucleotidyltransferase

(9-98)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15945.40 Da        Isoelectric Point: 7.2062

>T172650 WP_033005519.1 NZ_CP061470:c113292-112873 [Geobacillus zalihae]
MKHDVILNKVSIIERCLKRIDEEYDHDPQNLQNYTKQDSIILNLQRACEACIDLAMHIVAEQKFGLPQHSRDAFALLEEH
GVISPSVSKKMKAMVGFRNIAVHNYQQLNLGILQAIIDHHLDDFKHFAKAILDYAKKNG

Download         Length: 420 bp

>T172650 NZ_CP079838:2069506-2069661 [Salmonella enterica subsp. salamae]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTATCACCGTTGTAATGGCGGTGCTGGTAACGAGGAA
AGACCTCTGCGAGGTACGCATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACGGCTTACGAATCTGAGGAGTAA

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 15209.43 Da        Isoelectric Point: 4.9959

>AT172650 WP_020754944.1 NZ_CP061470:c113689-113282 [Geobacillus zalihae]
MPNEMETIIIQTLRPALHPFVIYLFGSAARGAMRSDSDVDIAFVSDGEPHDPYELFRLAGHLADKLGRDVDLVDLRQAST
VFQAQVVSSGKVIDCCDERKRMEFEMKTLKMYAKLNEERAPVLKRIAESGSVYET

Download         Length: 408 bp

>AT172650 NZ_CP079838:c2069494-2069436 [Salmonella enterica subsp. salamae]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTCTAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A063YVL8

Antitoxin

Source ID Structure
AlphaFold DB A0A063YXD9

References