Detailed information of TA system TA172644

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5008071..5009752
• Replicon: chromosome
• Accession: NZ_CP061404
• Organism: Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: HCV81_RS24840
• Protein ID: WP_048999664.1
• Coordinates: 5008071..5008988 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: HCV81_RS24845
• Protein ID: WP_059065443.1
• Coordinates: 5008994..5009752 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCV81_RS24820	5003377..5004897	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
HCV81_RS24825	5004894..5005892	+	999	WP_004186549.1	ribose ABC transporter permease	-
HCV81_RS24830	5005923..5006864	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
HCV81_RS24835	5006939..5007946	+	1008	WP_004210019.1	carbohydrate kinase family protein	-
HCV81_RS24840	5008071..5008988	-	918	WP_048999664.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
HCV81_RS24845	5008994..5009752	-	759	WP_059065443.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
HCV81_RS24850	5009838..5010566	-	729	WP_023288135.1	response regulator transcription factor	-
HCV81_RS24855	5010839..5012986	+	2148	WP_077598991.1	formate dehydrogenase subunit alpha	-
HCV81_RS24860	5012983..5013126	-	144	WP_022631365.1	hypothetical protein	-
HCV81_RS24865	5013680..5014366	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34743.22 Da
• Isoelectric Point: 5.4707

>T172644 WP_048999664.1 NZ_CP061404:c5008988-5008071 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALRGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIVANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T172644 NZ_CP079837:4014670-4015086 [Salmonella enterica subsp. salamae]
ATGAGTAGAACCTACATGCTGGATACCTGCATCTGTTCTTTCATTATGCGCGAGCAGCCGGAAGCTGTGCTGAAACGCCT
TGAACAGACCGTGTTGCGCCGCCATCGTATTGTGGTGTCGGCGATTACCTACGCCGAAATGCGTTTTGGCTGTACGGGCA
AAAAGGCCTCGCCGCGCCATGCCCAACTGGTCGATGCATTCTGTAGCCGCCTGGATGCCGTATTGGCCTGGGACCGGGCG
GCAGTGGATGCCACCACAGAGATCCGTGCCGTACTGGCCGCCGCCGGTACGCCGATTGGATCAAACGATGCGGCTATCGC
CGGCCATGCCATTGCGTCCGGGGCGATACTGGTCACTAATAACGTGAGGGAATTTGAGCGGGTACCGGGCTTGCAGTACG
AAGATTGGGTAAAATAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28568.92 Da
• Isoelectric Point: 10.0870

>AT172644 WP_059065443.1 NZ_CP061404:c5009752-5008994 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDAFACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHGAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT172644 NZ_CP079837:4014443-4014673 [Salmonella enterica subsp. salamae]
ATGCGAACCGTATCTGTATTTAAAAATGGCAATAACCGCGCGATCCGTCTTCCACGCGATCTGGATTTTGACGGCGTCAA
CGAACTTGAAATCTTCCGCGAAGGCGACACGATTATCCTACGCCCAGCCCGCCCCTCCTGGGGTTCGTTCCGCCATGAGG
AAAAAGCTAACCCGGACTTTCTAACGGAGCGCGAAGATATCGTCAGCGATGAGGGACGCTTTGAACTATGA