Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4847832..4848348 Replicon chromosome
Accession NZ_CP061404
Organism Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)


Gene name relE Uniprot ID A0A085DK79
Locus tag HCV81_RS24030 Protein ID WP_009309309.1
Coordinates 4847832..4848116 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HCV81_RS24035 Protein ID WP_002886901.1
Coordinates 4848106..4848348 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV81_RS24005 4843228..4843536 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HCV81_RS24010 4843621..4843794 + 174 WP_004222159.1 hypothetical protein -
HCV81_RS24015 4843797..4844540 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HCV81_RS24020 4844897..4847035 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
HCV81_RS24025 4847364..4847828 + 465 WP_049000498.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HCV81_RS24030 4847832..4848116 - 285 WP_009309309.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HCV81_RS24035 4848106..4848348 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HCV81_RS24040 4848426..4850336 - 1911 WP_049000497.1 BglG family transcription antiterminator -
HCV81_RS24045 4850359..4851513 - 1155 WP_049000495.1 lactonase family protein -
HCV81_RS24050 4851580..4852320 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11141.99 Da        Isoelectric Point: 10.3787

>T172643 WP_009309309.1 NZ_CP061404:c4848116-4847832 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNLRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T172643 NZ_CP079837:3358868-3359086 [Salmonella enterica subsp. salamae]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTGTCCGACAATGAACTGGCTGTATTTTACTCAGCGGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATCCCTTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT172643 WP_002886901.1 NZ_CP061404:c4848348-4848106 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT172643 NZ_CP079837:3358466-3358840 [Salmonella enterica subsp. salamae]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A085DK79

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References