Detailed information of TA system TA172632

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2546595..2548183
• Replicon: chromosome
• Accession: NZ_CP061404
• Organism: Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A6T928
• Locus tag: HCV81_RS12690
• Protein ID: WP_004176197.1
• Coordinates: 2546861..2548183 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: HCV81_RS12685
• Protein ID: WP_002904790.1
• Coordinates: 2546595..2546861 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HCV81_RS12660	2541746..2542669	+	924	WP_004184020.1	LysR family hpxDE operon transcriptional regulator HpxR	-
HCV81_RS12665	2542650..2543804	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
HCV81_RS12670	2544150..2545529	+	1380	WP_002904785.1	purine permease	-
HCV81_RS12675	2545507..2546007	+	501	WP_048999765.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
HCV81_RS12680	2546004..2546330	+	327	WP_002904788.1	hydroxyisourate hydrolase	-
HCV81_RS12685	2546595..2546861	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
HCV81_RS12690	2546861..2548183	+	1323	WP_004176197.1	type II toxin-antitoxin system HipA family toxin	Toxin
HCV81_RS12695	2548200..2549492	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
HCV81_RS12700	2549634..2550638	-	1005	WP_059065330.1	type 1 fimbrial protein	-
HCV81_RS12705	2550626..2553127	-	2502	WP_048999761.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49111.41 Da
• Isoelectric Point: 7.5357

>T172632 WP_004176197.1 NZ_CP061404:2546861-2548183 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T172632 NZ_CP079836:3716554-3716772 [Salmonella enterica subsp. salamae]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAACTATCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTTTACGACAAGATCCCTTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT172632 WP_002904790.1 NZ_CP061404:2546595-2546861 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT172632 NZ_CP079836:3716152-3716526 [Salmonella enterica subsp. salamae]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTTCGCTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Structures

Toxin

• AlphaFold DB: A6T928

Antitoxin

• AlphaFold DB: A0A0H3GXD8