Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 835762..836419 Replicon chromosome
Accession NZ_CP061404
Organism Klebsiella pneumoniae strain NU-CRE055

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HCV81_RS04170 Protein ID WP_002916310.1
Coordinates 836009..836419 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HCV81_RS04165 Protein ID WP_002916312.1
Coordinates 835762..836028 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV81_RS04140 830918..832351 - 1434 WP_059065114.1 6-phospho-beta-glucosidase -
HCV81_RS04145 832470..833198 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HCV81_RS04150 833248..833559 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
HCV81_RS04155 833723..834382 + 660 WP_002916317.1 hemolysin III family protein -
HCV81_RS04160 834533..835516 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HCV81_RS04165 835762..836028 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HCV81_RS04170 836009..836419 + 411 WP_002916310.1 protein YgfX Toxin
HCV81_RS04175 836426..836947 - 522 WP_004144730.1 flavodoxin FldB -
HCV81_RS04180 837048..837944 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HCV81_RS04185 837967..838680 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HCV81_RS04190 838686..840419 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T172631 WP_002916310.1 NZ_CP061404:836009-836419 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T172631 NZ_CP079836:2237929-2238032 [Salmonella enterica subsp. salamae]
GGCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT172631 WP_002916312.1 NZ_CP061404:835762-836028 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT172631 NZ_CP079836:c2238034-2237891 [Salmonella enterica subsp. salamae]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAGTCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References