Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4924771..4925287 Replicon chromosome
Accession NZ_CP061399
Organism Klebsiella pneumoniae strain NU-CRE085

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HCV82_RS24190 Protein ID WP_002886902.1
Coordinates 4924771..4925055 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HCV82_RS24195 Protein ID WP_002886901.1
Coordinates 4925045..4925287 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV82_RS24165 4920255..4920563 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HCV82_RS24170 4920648..4920821 + 174 WP_002886906.1 hypothetical protein -
HCV82_RS24175 4920824..4921567 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HCV82_RS24180 4921924..4924062 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HCV82_RS24185 4924303..4924767 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HCV82_RS24190 4924771..4925055 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HCV82_RS24195 4925045..4925287 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HCV82_RS24200 4925365..4927275 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HCV82_RS24205 4927298..4928452 - 1155 WP_002886900.1 lactonase family protein -
HCV82_RS24210 4928518..4929258 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T172624 WP_002886902.1 NZ_CP061399:c4925055-4924771 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T172624 NZ_CP079827:981209-981502 [Pseudomonas sp. HD6515]
ATGTTTCTCGTTGAACAGACGGAAAGCTTTGCCGCTTGGCTATCGAGCTTGAGAGATTTGAGGGCCAGGCTGGCGATAGG
TCGTAGGCTGGAGCGAGCAGCGGCGGGCAATCTTGGTGACTTCAAGTGGCTTGGAGGCGGTATTGGTGAGCTTCGCATCG
ACGTAGCTGCCGGTTATCGCGTCTATTTCACGCAAAAGGGGCAGAGGTTGGTTTTACTGCTGGTCGGCGGCGACAAGTCC
ACCCAAGCCGCCGACATCCTCAACGCCAGAAAGCTGCTGAAGGAGATGAAATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT172624 WP_002886901.1 NZ_CP061399:c4925287-4925045 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT172624 NZ_CP079827:981499-981795 [Pseudomonas sp. HD6515]
ATGAGCGAAAAATTGATCCCGTTTGATATGGCAGCCTTGTTGAGCAGCGATGAGGCAATCAGTGAATACCTTAGCCAGGT
GCTATCAAATGGCGATACCGAGGAAATCATTCGAGCACTTGGCCATATCGCTCGTGCACGGGGCATGACACATATTGCTA
CGGAGAGTGGGCTGGGTAGAGAAAGCCTGTACAAGGCGCTGAGCCCTGGCGCGAAGCCTCGTTTTGACACTGTATTGAGG
GTCATTCGTGCTCTGGGGGTGGACCTTCTCGTTCAGCCACATGCAATGACCCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References