Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4258807..4259426 Replicon chromosome
Accession NZ_CP061396
Organism Klebsiella pneumoniae strain NU-CRE193

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag HCV83_RS21080 Protein ID WP_002892050.1
Coordinates 4259208..4259426 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag HCV83_RS21075 Protein ID WP_002892066.1
Coordinates 4258807..4259181 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV83_RS21065 4253959..4255152 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
HCV83_RS21070 4255175..4258321 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
HCV83_RS21075 4258807..4259181 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
HCV83_RS21080 4259208..4259426 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
HCV83_RS21085 4259585..4260151 + 567 WP_002892030.1 maltose O-acetyltransferase -
HCV83_RS21090 4260123..4260263 - 141 WP_004147370.1 hypothetical protein -
HCV83_RS21095 4260284..4260754 + 471 WP_002892026.1 YlaC family protein -
HCV83_RS21100 4260729..4262180 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
HCV83_RS21105 4262281..4262979 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
HCV83_RS21110 4262976..4263116 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
HCV83_RS21115 4263116..4263379 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T172603 WP_002892050.1 NZ_CP061396:4259208-4259426 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T172603 NZ_CP079807:c4022843-4022526 [Klebsiella pneumoniae subsp. pneumoniae]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAATTAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT172603 WP_002892066.1 NZ_CP061396:4258807-4259181 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT172603 NZ_CP079807:c4022533-4022246 [Klebsiella pneumoniae subsp. pneumoniae]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTGGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTAACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGCGGTATAAAGCACCCGCAAGTTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References