Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 870939..871596 Replicon chromosome
Accession NZ_CP061396
Organism Klebsiella pneumoniae strain NU-CRE193

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag HCV83_RS04395 Protein ID WP_002916310.1
Coordinates 871186..871596 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag HCV83_RS04390 Protein ID WP_002916312.1
Coordinates 870939..871205 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV83_RS04365 866095..867528 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
HCV83_RS04370 867647..868375 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
HCV83_RS04375 868425..868736 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
HCV83_RS04380 868900..869559 + 660 WP_002916317.1 hemolysin III family protein -
HCV83_RS04385 869710..870693 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
HCV83_RS04390 870939..871205 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
HCV83_RS04395 871186..871596 + 411 WP_002916310.1 protein YgfX Toxin
HCV83_RS04400 871603..872124 - 522 WP_002916308.1 flavodoxin FldB -
HCV83_RS04405 872225..873121 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
HCV83_RS04410 873144..873857 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
HCV83_RS04415 873863..875596 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T172593 WP_002916310.1 NZ_CP061396:871186-871596 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T172593 NZ_CP079802:c4243989-4243672 [Klebsiella variicola]
ATGTTCAGATTGGTTGTGCATGTGGACGTTAAAAAGGAATTGCAGGCGCTTCCGCCCATTGTCCAGGCGAAGATGATCCG
GCAAATAGACAAGTTACGCCAAAATCCCACCGCGCTGAGAGAACCTGACAGTAAACCGCTGGGGCAGGGGCTATTTGAAA
TTCGTGCGTTAGGTTCGGTACAGGGGCGAGGGATCTACGTTTTTCAGCAAGGCAAGACGCTCTTTCTGCTACGGGTTTTT
GTCAAGAAAACGCAAAAAACCCCGTCATCGGAAATTCGCCTGGCGCTGAAGCGATTAGAGGAGATGCGCAATGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT172593 WP_002916312.1 NZ_CP061396:870939-871205 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT172593 NZ_CP079802:c4243679-4243392 [Klebsiella variicola]
ATGAGTAAAAAGATCATTGACTGGGATACGTTAAAAACAGAACTGCTTAGCCAGCCTGAGGTTCAGGCTGCATTCGATGC
GCAAGAACGTCAACAGCGATTACGTACTATGCTGGCGCAATGGCGCGAGCAGGCGGGGCTGACCCGAGCCCAGGTGGCGC
AGAGGATGGGGGTGAGTGCGCCGACGGTCTCCAGAATGGAAGCCAATATCACCCGCGCCAGTCTGGATACCTTAACGCGA
TACGCGTTAGCCTGTGGAATAAAGCACCCACAAATTTTACTTTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References