Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4869595..4870111 Replicon chromosome
Accession NZ_CP061385
Organism Klebsiella pneumoniae strain NU-CRE213

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag HCV85_RS24225 Protein ID WP_002886902.1
Coordinates 4869595..4869879 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag HCV85_RS24230 Protein ID WP_002886901.1
Coordinates 4869869..4870111 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HCV85_RS24200 4865079..4865387 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
HCV85_RS24205 4865472..4865645 + 174 WP_002886906.1 hypothetical protein -
HCV85_RS24210 4865648..4866391 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
HCV85_RS24215 4866748..4868886 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
HCV85_RS24220 4869127..4869591 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
HCV85_RS24225 4869595..4869879 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
HCV85_RS24230 4869869..4870111 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
HCV85_RS24235 4870189..4872099 - 1911 WP_004152270.1 BglG family transcription antiterminator -
HCV85_RS24240 4872122..4873276 - 1155 WP_002886900.1 lactonase family protein -
HCV85_RS24245 4873342..4874082 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T172567 WP_002886902.1 NZ_CP061385:c4869879-4869595 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T172567 NZ_CP079781:c5187696-5187313 [Klebsiella pneumoniae subsp. pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT172567 WP_002886901.1 NZ_CP061385:c4870111-4869869 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT172567 NZ_CP079781:c5187938-5187696 [Klebsiella pneumoniae subsp. pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References