Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 7090050..7090642 Replicon chromosome
Accession NZ_CP061379
Organism Bradyrhizobium genosp. B strain BDV5040

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag IC761_RS33295 Protein ID WP_195800844.1
Coordinates 7090050..7090238 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag IC761_RS33300 Protein ID WP_195800845.1
Coordinates 7090244..7090642 (+) Length 133 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC761_RS33270 7085177..7086346 - 1170 WP_195800839.1 4-hydroxybenzoate 3-monooxygenase -
IC761_RS33275 7086611..7087627 + 1017 WP_195800840.1 TRAP transporter substrate-binding protein -
IC761_RS33280 7087702..7088211 + 510 WP_195800841.1 TRAP transporter small permease -
IC761_RS33285 7088214..7089533 + 1320 WP_195800842.1 TRAP transporter permease -
IC761_RS33290 7089545..7090006 + 462 WP_195800843.1 DUF3237 domain-containing protein -
IC761_RS33295 7090050..7090238 + 189 WP_195800844.1 type II toxin-antitoxin system HicA family toxin Toxin
IC761_RS33300 7090244..7090642 + 399 WP_195800845.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IC761_RS33305 7090751..7091560 + 810 WP_195800846.1 crotonase/enoyl-CoA hydratase family protein -
IC761_RS33310 7091557..7093440 + 1884 WP_195800847.1 feruloyl-CoA synthase -
IC761_RS33315 7093466..7094227 + 762 WP_025575316.1 SDR family NAD(P)-dependent oxidoreductase -
IC761_RS33320 7094241..7094660 + 420 WP_195800848.1 acyl-CoA thioesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 7083981..7085078 1097


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(4-124)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7015.16 Da        Isoelectric Point: 11.9739

>T172530 WP_195800844.1 NZ_CP061379:7090050-7090238 [Bradyrhizobium genosp. B]
MNSRDIISALQRDGWVQVAQKGSHVQFKHLTKTGRVTVPHPKRDIPLGTLKSIERQSGLKLR

Download         Length: 189 bp

>T172530 NZ_CP079777:c111650-111363 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin


Download         Length: 133 a.a.        Molecular weight: 14298.04 Da        Isoelectric Point: 4.1961

>AT172530 WP_195800845.1 NZ_CP061379:7090244-7090642 [Bradyrhizobium genosp. B]
MRHYIGLIRKDADSDFGVSFPDLPGVVTAGTTLDEARDMAEEALAFHLEGMEEDGEAIPEPSSLDEIMSNPENRSGVAIL
VSVKDDQPKIVRVNVTLPGDVLEQIDKYAEAHGYTRSGLLAQAAKRMITEAA

Download         Length: 399 bp

>AT172530 NZ_CP079777:c111889-111650 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGCGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References