Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1211058..1211617 Replicon chromosome
Accession NZ_CP061379
Organism Bradyrhizobium genosp. B strain BDV5040

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IC761_RS05780 Protein ID WP_195802326.1
Coordinates 1211246..1211617 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IC761_RS05775 Protein ID WP_195802325.1
Coordinates 1211058..1211249 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IC761_RS05745 1206479..1207225 + 747 WP_195802319.1 YebC/PmpR family DNA-binding transcriptional regulator -
IC761_RS05750 1207318..1207845 + 528 WP_195802320.1 crossover junction endodeoxyribonuclease RuvC -
IC761_RS05755 1207842..1208459 + 618 WP_195802321.1 Holliday junction branch migration protein RuvA -
IC761_RS05760 1208501..1208920 + 420 WP_195802322.1 cytidine deaminase -
IC761_RS05765 1208917..1209966 + 1050 WP_195802323.1 Holliday junction branch migration DNA helicase RuvB -
IC761_RS05770 1210092..1211006 + 915 WP_195802324.1 metallophosphoesterase -
IC761_RS05775 1211058..1211249 + 192 WP_195802325.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
IC761_RS05780 1211246..1211617 + 372 WP_195802326.1 PIN domain-containing protein Toxin
IC761_RS05785 1211626..1212072 + 447 WP_195802327.1 tol-pal system-associated acyl-CoA thioesterase -
IC761_RS05790 1212152..1212619 + 468 WP_195802328.1 nuclear transport factor 2 family protein -
IC761_RS05795 1212662..1213366 - 705 WP_195802329.1 type 1 glutamine amidotransferase -
IC761_RS05800 1213390..1214289 - 900 WP_195802330.1 LysR family transcriptional regulator -
IC761_RS05805 1214440..1215396 + 957 WP_195802331.1 N-carbamoyl-D-amino-acid hydrolase -
IC761_RS05810 1215441..1216268 + 828 WP_195802332.1 ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-113)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13360.48 Da        Isoelectric Point: 6.0749

>T172527 WP_195802326.1 NZ_CP061379:1211246-1211617 [Bradyrhizobium genosp. B]
MKVLADTSIWVDHLRRADERLAGLLNHGDIVIHPFVIGELLLGGVPKGSDMLDDLNTLPRATVAGNDEVLEFIVKRRLTG
LGIGYVDAHLLASTILTAEASIWTRDKRLLAAARSLNLAADIQ

Download         Length: 372 bp

>T172527 NZ_CP079776:c12731-12354 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAGCTTATTGCAATTCATGATGCGAATATAAGCCGCTACGGCGGCCTGCCAGGCATGCC
AGATTCGGGAAGAGCTGAGGCTATTATCGGGAGAGTCCAGGCCAGAGTTGCATATGAAGAGATTACCGACCTTTTCGAAG
TCTCCGCAACTTACCTGGTGGCTACTGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
TTGTTATTTCTGCGCCGTAACGGTGTGCAGGTATATGATTCACCAGAACTGGCAGAGCTTACTGTGGGGGCTGCGACCGG
AGAGGTATCCGTATCTACTGTCGTTGCCACGTTACGTAGATTGTATGGTACGGCGTAG

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7039.20 Da        Isoelectric Point: 11.2749

>AT172527 WP_195802325.1 NZ_CP061379:1211058-1211249 [Bradyrhizobium genosp. B]
MRTTIAIDDELFAKAQEFAGVSEKSAVVREALKAFVEREAARRLARMGGTEPKVKAPPRRRPK

Download         Length: 192 bp

>AT172527 NZ_CP079776:c12952-12731 [Escherichia coli]
ATGCAATCTATTAACTTCCGTACCGCACGCAGCAATCTTACCGAAGTGCTCAACAATGTTGAAGCCGGAGAAGAGGTTGA
AATCACCCGTAGAGGCCGTGAGCCAGCTGTAATTGTCAGCAAGGCCACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACTCTGGACACCACCAATAAGAAACTGGTTAACCGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References