Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/-
Location 3521057..3522278 Replicon chromosome
Accession NZ_CP061376
Organism Pseudomonas aeruginosa strain HS17-127

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag ICI41_RS16275 Protein ID WP_003102740.1
Coordinates 3521700..3522278 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag ICI41_RS16270 Protein ID WP_043089772.1
Coordinates 3521057..3521611 (+) Length 185 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI41_RS16245 (ICI41_16245) 3516625..3517176 + 552 WP_003102727.1 XRE family transcriptional regulator -
ICI41_RS16250 (ICI41_16250) 3517173..3517571 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
ICI41_RS16255 (ICI41_16255) 3517584..3517907 - 324 WP_023119961.1 multidrug efflux SMR transporter -
ICI41_RS16260 (ICI41_16260) 3518238..3518699 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
ICI41_RS16265 (ICI41_16265) 3518704..3520899 + 2196 WP_043089773.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
ICI41_RS16270 (ICI41_16270) 3521057..3521611 + 555 WP_043089772.1 helix-turn-helix transcriptional regulator Antitoxin
ICI41_RS16275 (ICI41_16275) 3521700..3522278 + 579 WP_003102740.1 HD domain-containing protein Toxin
ICI41_RS16280 (ICI41_16280) 3522387..3523574 - 1188 WP_021264658.1 HlyD family efflux transporter periplasmic adaptor subunit -
ICI41_RS16285 (ICI41_16285) 3523564..3525735 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
ICI41_RS16290 (ICI41_16290) 3525725..3527002 - 1278 WP_019396178.1 TolC family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(16-170)

Antitoxin

(14-65)


Sequences


Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T172518 WP_003102740.1 NZ_CP061376:3521700-3522278 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T172518 NZ_CP079772:4193937-4194251 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20484.66 Da        Isoelectric Point: 8.1590

>AT172518 WP_043089772.1 NZ_CP061376:3521057-3521611 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGTRLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT172518 NZ_CP079772:4194248-4194664 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07


Antitoxin

Source ID Structure

References