Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143625..144130 Replicon chromosome
Accession NZ_CP061376
Organism Pseudomonas aeruginosa strain HS17-127

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag ICI41_RS00660 Protein ID WP_003083773.1
Coordinates 143625..143906 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag ICI41_RS00665 Protein ID WP_003083775.1
Coordinates 143903..144130 (-) Length 76 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ICI41_RS00635 (ICI41_00635) 138876..140225 + 1350 WP_003142411.1 C4-dicarboxylate transporter DctA -
ICI41_RS00640 (ICI41_00640) 140274..140960 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
ICI41_RS00645 (ICI41_00645) 141061..141795 + 735 WP_043089546.1 GntR family transcriptional regulator -
ICI41_RS00650 (ICI41_00650) 141975..142385 + 411 WP_003101225.1 aegerolysin family protein -
ICI41_RS00655 (ICI41_00655) 142417..143325 - 909 WP_003083769.1 LysR family transcriptional regulator -
ICI41_RS00660 (ICI41_00660) 143625..143906 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
ICI41_RS00665 (ICI41_00665) 143903..144130 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
ICI41_RS00670 (ICI41_00670) 144306..144926 - 621 WP_003101226.1 hypothetical protein -
ICI41_RS00675 (ICI41_00675) 145027..145527 + 501 WP_003101228.1 LEA type 2 family protein -
ICI41_RS00680 (ICI41_00680) 145600..145941 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
ICI41_RS00685 (ICI41_00685) 146023..147450 - 1428 WP_003083784.1 GABA permease -
ICI41_RS00690 (ICI41_00690) 147619..149112 - 1494 WP_016263977.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T172516 WP_003083773.1 NZ_CP061376:c143906-143625 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T172516 NZ_CP079772:3724690-3724797 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT172516 WP_003083775.1 NZ_CP061376:c144130-143903 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT172516 NZ_CP079772:c3724642-3724576 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 6XRW


Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References