Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) rlegTA/AbiEii-AbiEi
Location 4707380..4708899 Replicon chromosome
Accession NZ_CP061375
Organism Xanthomonas oryzae pv. oryzae strain IXO608

Toxin (Protein)


Gene name rlegT Uniprot ID A0A0K0GMB6
Locus tag IXO608_RS22230 Protein ID WP_011259680.1
Coordinates 4707976..4708899 (+) Length 308 a.a.

Antitoxin (Protein)


Gene name rlegA Uniprot ID A0A854CLN1
Locus tag IXO608_RS22225 Protein ID WP_011409027.1
Coordinates 4707380..4707979 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IXO608_RS22190 (IXO608_022015) 4703062..4703598 - 537 WP_011409032.1 lipocalin family protein -
IXO608_RS22200 4703868..4704335 - 468 WP_181718264.1 hypothetical protein -
IXO608_RS22205 4704316..4704606 - 291 WP_011409031.1 hypothetical protein -
IXO608_RS22210 (IXO608_022035) 4705105..4706136 + 1032 WP_263121766.1 IS630 family transposase -
IXO608_RS22215 (IXO608_022040) 4706118..4706693 - 576 WP_011409029.1 BrxE family protein -
IXO608_RS22220 (IXO608_022045) 4706725..4707015 - 291 WP_228329665.1 FaeA/PapI family transcriptional regulator -
IXO608_RS22225 (IXO608_022050) 4707380..4707979 + 600 WP_011409027.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein Antitoxin
IXO608_RS22230 (IXO608_022055) 4707976..4708899 + 924 WP_011259680.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IXO608_RS22235 4708979..4709449 - 471 WP_228383551.1 helix-turn-helix domain-containing protein -
IXO608_RS22240 (IXO608_022070) 4709915..4710157 + 243 WP_011409025.1 hypothetical protein -
IXO608_RS22245 (IXO608_022075) 4710609..4711574 - 966 Protein_4245 IS1595 family transposase -
IXO608_RS22250 (IXO608_022080) 4711669..4712157 + 489 WP_011409022.1 hypothetical protein -
IXO608_RS22255 (IXO608_022085) 4712174..4712706 - 533 Protein_4247 protein N-lysine methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(41-269)

Antitoxin

Transcriptional regulator, AbiEi antitoxin

(7-52)


Sequences

Toxin        


Download         Length: 308 a.a.        Molecular weight: 34114.16 Da        Isoelectric Point: 5.4588

>T172515 WP_011259680.1 NZ_CP061375:4707976-4708899 [Xanthomonas oryzae pv. oryzae]
MNEPDKSRRTVAASVRARLLNKARAERLDFNLLLTRYALERVLYRLSVSEQQGQFLLKGALLFDIWFDIPHRPTHDADLL
GFGSTEIPHLEDLFRRISQIASDDGIVFQADSVKAAEIRKEANYAGVRVTMIGLLDGARCTVQIDIGFGDAVTPGPDNVQ
YPVILDGMPQPQLRVYPRYTVVAEKLEAMVKLGILNSRMKDYFDLWVLAGHSDFDGAVLATAIRATFECRGTAIPPGAPL
GLTDEFGLDEQKTKQWQAFLRKNTLEPMPLTTVIEALREFVLPVLAALAAGEGFDRQWRAGAGWDAA

Download         Length: 924 bp

>T172515 NZ_CP079772:c3065238-3065065 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22037.74 Da        Isoelectric Point: 10.1240

>AT172515 WP_011409027.1 NZ_CP061375:4707380-4707979 [Xanthomonas oryzae pv. oryzae]
MDTTVDKLLELVRTRGLLRPHDLAPLGIPRVALTRAVRRGQLERVGRGLYGLVARPVSAHGTLAEVARRVPKGVVCLLSA
LRVHDLTTQAPFEVWLAIDNKAAAPKLDYPPLRLVRFSGPALSEGVEEHVVDGVPVHVTSVAKTVADCFKYRNKIGIDVA
LEALREAWVARRMTSDEIWHYAKIDRVANVMRPYLESLA

Download         Length: 600 bp

>AT172515 NZ_CP079772:c3065562-3065266 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K0GMB6

Antitoxin

Source ID Structure
AlphaFold DB A0A854CLN1

References