Detailed information of TA system TA172511

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 339042..339598
• Replicon: chromosome
• Accession: NZ_CP061375
• Organism: Xanthomonas oryzae pv. oryzae strain IXO608

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IXO608_RS01495
• Protein ID: WP_229001948.1
• Coordinates: 339347..339598 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A854CIX2
• Locus tag: IXO608_RS01490
• Protein ID: WP_011408759.1
• Coordinates: 339042..339320 (+)
• Length: 93 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IXO608_RS01470 (IXO608_001485)	334159..334716	-	558	WP_011259349.1	DNA-3-methyladenine glycosylase	-
IXO608_RS01475 (IXO608_001490)	334866..335831	-	966	WP_109181928.1	IS1595-like element ISXo5 family transposase	-
IXO608_RS01480 (IXO608_001495)	336412..337596	+	1185	WP_263117673.1	IS256-like element IS1113 family transposase	-
IXO608_RS01485 (IXO608_001505)	338502..338846	+	345	WP_199285675.1	hypothetical protein	-
IXO608_RS01490 (IXO608_001510)	339042..339320	+	279	WP_011408759.1	CopG family ribbon-helix-helix protein	Antitoxin
IXO608_RS01495 (IXO608_001515)	339347..339598	+	252	WP_229001948.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IXO608_RS01500 (IXO608_001520)	339859..340056	+	198	WP_153296741.1	hypothetical protein	-
IXO608_RS01505 (IXO608_001525)	340125..340379	+	255	WP_223293127.1	hypothetical protein	-
IXO608_RS01510	340596..340715	+	120	Protein_291	IS3 family transposase	-
IXO608_RS01515	340684..340812	+	129	WP_012444694.1	hypothetical protein	-
IXO608_RS01525 (IXO608_001540)	341243..341644	-	402	WP_011259345.1	H-NS family nucleoid-associated regulatory protein	-
IXO608_RS01530 (IXO608_001545)	341866..342042	+	177	Protein_294	DUF3606 domain-containing protein	-
IXO608_RS01535 (IXO608_001555)	342324..342640	+	317	Protein_295	ATP-dependent DNA ligase	-
IXO608_RS01540 (IXO608_001560)	342737..343828	-	1092	WP_011408756.1	ribonuclease D	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-81)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9603.92 Da
• Isoelectric Point: 9.9718

>T172511 WP_229001948.1 NZ_CP061375:339347-339598 [Xanthomonas oryzae pv. oryzae]
MLRLREFLRPKNPDAARRAGEAIRRGVQALGAHPRMGRLIEDLSEQYREWLIDFGDSGYVARYRFDGDTVTILAVRHQKE
AGY

Nucleotide

• Length: 252 bp

>T172511 NZ_CP079772:c2525871-2525473 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGATCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 93 a.a.
• Molecular weight: 10826.11 Da
• Isoelectric Point: 4.9736

>AT172511 WP_011408759.1 NZ_CP061375:339042-339320 [Xanthomonas oryzae pv. oryzae]
MVTATSIKLDDELKGRVQHLAESRRRTPHWIMREAIEQYVEREEKREALNRDTLKAWDEFQATGLHVTAEEVDKWLASWG
TDDELPPPECHK

Nucleotide

• Length: 279 bp

>AT172511 NZ_CP079772:c2526167-2525874 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Antitoxin

• AlphaFold DB: A0A854CIX2